CLINICAL ACTIVITY OF RAF INHIBITOR TOVORAFENIB ACCORDING TO PRIOR MAPK INHIBITOR TREATMENT IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY

被引：0

作者：

Dong-Anh Khuong-Quang ^{[1
]}

Nysom, Karsten ^{[2
]}

Landi, Daniel ^{[3
]}

Ziegler, David ^{[4
]}

Driever, Pablo Hernaiz ^{[5
,6
,7
]}

Leary, Sarah ^{[8
]}

Bailey, Simon ^{[9
]}

van der Lugt, Jasper ^{[10
]}

Perreault, Sebastien ^{[11
]}

Waanders, Angela ^{[12
]}

Baxter, Patricia ^{[13
]}

Witt, Olaf ^{[14
,15
,16
]}

Hargrave, Darren ^{[17
]}

McCowage, Geoffrey ^{[18
]}

Hansford, Jordan ^{[19
]}

Toledano, Helen ^{[20
]}

Oren, Liat ^{[21
]}

Tan, Enrica E. K. ^{[22
]}

Gerber, Nicolas ^{[23
]}

Kang, Hyoung Jin ^{[24
]}

Larouche, Valerie ^{[25
]}

Abdelbaki, Mohamed S. ^{[26
]}

Cornelio, Izzy ^{[27
]}

Kim, Yeonhee ^{[27
]}

Walter, Ashley ^{[27
]}

Manley, Peter ^{[27
]}

Kilburn, Lindsay ^{[28
]}

机构：

[1] Royal Childrens Hosp Melbourne, Melbourne, Vic, Australia

[2] Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark

[3] Duke Univ, Durham, NC USA

[4] Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, Australia

[5] Charite Univ Med Berlin, German HIT LOGGICRegistry LGG Children & Adolesce, Berlin, Germany

[6] Free Univ Berlin, Berlin, Germany

[7] Humboldt Univ, Berlin, Germany

[8] Seattle Childrens, Canc & Blood Disorders Ctr, Seattle, WA USA

[9] Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne, Tyne & Wear, England

[10] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[11] CHU St Justine, Montreal, PQ, Canada

[12] Ann & Robert H Lurie Childrens Hosp, Chicago, IL USA

[13] Texas Childrens Hosp, Texas Childrens Canc Ctr, Houston, TX USA

[14] Heidelberg Univ Hosp, Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany

[15] German Canc Res Ctr, Heidelberg, Germany

[16] Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[17] UCL Great Ormond St Inst Child Hlth, London, England

[18] Sydney Childrens Hosp Network, Westmead, NSW, Australia

[19] Royal Childrens Hosp Melbourne, Childrens Canc Ctr, Parkville, Vic, Australia

[20] Childrens Med Ctr Israel, Petah Tiqwa, Israel

[21] Rambam Healthcare Campus, Haifa, Israel

[22] KK Womens & Childrens Hosp, Singapore, Singapore

[23] Univ Childrens Hosp, Zurich, Switzerland

[24] Seoul Natl Univ, Dept Pediat, Coll Med, Canc Res Inst,Childrens Hosp, Seoul, South Korea

[25] Univ Laval CHUL, CHU Quebec, Quebec City, PQ, Canada

[26] St Louis Childrens Hosp NCH, St Louis, MO USA

[27] Day One Biopharmaceut, Brisbane, CA USA

[28] Childrens Natl Hosp, Washington, DC USA

来源：

NEURO-ONCOLOGY | 2023年 / 25卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CTNI-37

引用

页数：2

共 21 条

[21] SJ901: PHASE I/II EVALUATION OF SINGLE AGENT MIRDAMETINIB (PD-0325901), A BRAIN-PENETRANT MEK1/2 INHIBITOR, FOR THE TREATMENT OF CHILDREN, ADOLESCENTS, AND YOUNG ADULTS WITH LOW-GRADE GLIOMA (LGG)
Vinitsky, Anna
Chiang, Jason
Bag, Asim K.
Campagne, Olivia
Stewart, Clinton F.
Dunphy, Paige
Shulkin, Barry
Li, Qian
Lin, Tong
Hoehn, Mary Ellen
Johnson, Jason N.
Towbin, Jeffrey A.
Khan, Raja
Tatevossian, Ruth G.
Armstrong, Gregory T.
Potter, Brian
Conklin, Heather
Shearer, Todd
Scott, Susan
Robinson, Giles W.
NEURO-ONCOLOGY, 2022, 24 : 92 - 92

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