CLINICAL ACTIVITY OF RAF INHIBITOR TOVORAFENIB ACCORDING TO PRIOR MAPK INHIBITOR TREATMENT IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY

被引：0

作者：

Dong-Anh Khuong-Quang ^{[1
]}

Nysom, Karsten ^{[2
]}

Landi, Daniel ^{[3
]}

Ziegler, David ^{[4
]}

Driever, Pablo Hernaiz ^{[5
,6
,7
]}

Leary, Sarah ^{[8
]}

Bailey, Simon ^{[9
]}

van der Lugt, Jasper ^{[10
]}

Perreault, Sebastien ^{[11
]}

Waanders, Angela ^{[12
]}

Baxter, Patricia ^{[13
]}

Witt, Olaf ^{[14
,15
,16
]}

Hargrave, Darren ^{[17
]}

McCowage, Geoffrey ^{[18
]}

Hansford, Jordan ^{[19
]}

Toledano, Helen ^{[20
]}

Oren, Liat ^{[21
]}

Tan, Enrica E. K. ^{[22
]}

Gerber, Nicolas ^{[23
]}

Kang, Hyoung Jin ^{[24
]}

Larouche, Valerie ^{[25
]}

Abdelbaki, Mohamed S. ^{[26
]}

Cornelio, Izzy ^{[27
]}

Kim, Yeonhee ^{[27
]}

Walter, Ashley ^{[27
]}

Manley, Peter ^{[27
]}

Kilburn, Lindsay ^{[28
]}

机构：

[1] Royal Childrens Hosp Melbourne, Melbourne, Vic, Australia

[2] Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark

[3] Duke Univ, Durham, NC USA

[4] Sydney Childrens Hosp, Kids Canc Ctr, Randwick, NSW, Australia

[5] Charite Univ Med Berlin, German HIT LOGGICRegistry LGG Children & Adolesce, Berlin, Germany

[6] Free Univ Berlin, Berlin, Germany

[7] Humboldt Univ, Berlin, Germany

[8] Seattle Childrens, Canc & Blood Disorders Ctr, Seattle, WA USA

[9] Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne, Tyne & Wear, England

[10] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[11] CHU St Justine, Montreal, PQ, Canada

[12] Ann & Robert H Lurie Childrens Hosp, Chicago, IL USA

[13] Texas Childrens Hosp, Texas Childrens Canc Ctr, Houston, TX USA

[14] Heidelberg Univ Hosp, Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany

[15] German Canc Res Ctr, Heidelberg, Germany

[16] Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[17] UCL Great Ormond St Inst Child Hlth, London, England

[18] Sydney Childrens Hosp Network, Westmead, NSW, Australia

[19] Royal Childrens Hosp Melbourne, Childrens Canc Ctr, Parkville, Vic, Australia

[20] Childrens Med Ctr Israel, Petah Tiqwa, Israel

[21] Rambam Healthcare Campus, Haifa, Israel

[22] KK Womens & Childrens Hosp, Singapore, Singapore

[23] Univ Childrens Hosp, Zurich, Switzerland

[24] Seoul Natl Univ, Dept Pediat, Coll Med, Canc Res Inst,Childrens Hosp, Seoul, South Korea

[25] Univ Laval CHUL, CHU Quebec, Quebec City, PQ, Canada

[26] St Louis Childrens Hosp NCH, St Louis, MO USA

[27] Day One Biopharmaceut, Brisbane, CA USA

[28] Childrens Natl Hosp, Washington, DC USA

来源：

NEURO-ONCOLOGY | 2023年 / 25卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CTNI-37

引用

页数：2

共 21 条

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Kilburn, Lindsay Baker
Khuong-Quang, Dong-Anh
Nysom, Karsten
Landi, Daniel B.
Ziegler, David Simon
Driever, Pablo Hernaiz
Leary, Sarah
Bailey, Simon
Van der Lugt, Jasper
Perreault, Sebastien
Waanders, Angela Jae
Baxter, Patricia Ann
Witt, Olaf
Hargrave, Darren R.
McCowage, Geoffrey Brian
Zhao, Xin
Da Costa, Daniel
Cox, Michael Craig
Manley, Peter
Hansford, Jordan
JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
[2] CLINICAL ACTIVITY OF PAN-RAF INHIBITOR TOVORAFENIB IN THE REGISTRATIONAL PEDIATRIC LOWGRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY
Kilburn, Lindsay
Khuong-Quang, Dong-Anh
Nysom, Karsten
Landi, Daniel
Ziegler, David
Driever, Pablo Hernaiz
Leary, Sarah
Bailey, Simon
Van der Lugt, Jasper
Perreault, Sebastien
Waanders, Angela
Baxter, Patricia
Witt, Olaf
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Hansford, Jordan
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[3] CLINICAL ACTIVITY AND SAFETY OF THE RAF INHIBITOR TOVORAFENIB IN PATIENTS WITH OPTIC PATHWAY GLIOMAS IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY
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Qiu, Jiaheng
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[4] FIREFLY-1 (PNOC026): PHASE 2 STUDY OF PAN-RAF INHIBITOR TOVORAFENIB IN PEDIATRIC AND YOUNG ADULT PATIENTS WITH RAF-ALTERED RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA OR ADVANCED SOLID TUMORS
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Driever, Pablo Hernaiz
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Hassall, Timothy
Jabado, Nada
Kang, Hyoung Jin
Larouche, Valerie
Toledano, Helen
Kline, Cassie
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Gardner, Sharon
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[5] HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN THE PHASE 2 FIREFLY-1 (PNOC026) TRIAL OF THE TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY (R/R) PEDIATRIC LOW-GRADE GLIOMA (PLGG)
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Witt, Olaf
Kang, Hyoung Jin
Hassall, Timothy E.
Han, Jung Woo
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Oren, Liat
Tan, Enrica E. K.
Mueller, Sabine
Kilburn, Lindsay B.
Nysom, Karsten
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van der Lugt, Jasper
Leary, Sarah E. S.
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[6] The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
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Driever, Pablo Hernaiz
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Perreault, Sebastien
McCowage, Geoffrey
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Ziegler, David S.
Witt, Olaf
Baxter, Patricia A.
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Oren, Michal Yalon
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Larouche, Valerie
Kline, Cassie
Abdelbaki, Mohamed S.
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Gerber, Nicolas U.
Whipple, Nicholas S.
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[7] The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
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Khuong-Quang, Dong-Anh
Hansford, Jordan R.
Landi, Daniel
van der Lugt, Jasper
Leary, Sarah E. S.
Driever, Pablo Hernaiz
Bailey, Simon
Perreault, Sebastien
McCowage, Geoffrey
Waanders, Angela J.
Ziegler, David S.
Witt, Olaf
Baxter, Patricia A.
Kang, Hyoung Jin
Hassall, Timothy E.
Han, Jung Woo
Hargrave, Darren
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Yalon Oren, Michal
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Larouche, Valerie
Kline, Cassie
Abdelbaki, Mohamed S.
Jabado, Nada
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Gerber, Nicolas U.
Whipple, Nicholas S.
Segal, Devorah
Chi, Susan N.
Oren, Liat
Tan, Enrica E. K.
Mueller, Sabine
Cornelio, Izzy
McLeod, Lisa
Zhao, Xin
Walter, Ashley
Da Costa, Daniel
Manley, Peter
Blackman, Samuel C.
Packer, Roger J.
Nysom, Karsten
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[8] Type II RAF inhibitor tovorafenib for the treatment of pediatric low-grade glioma
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[9] TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY PEDIATRIC LOW-GRADE GLIOMA (PLGG): REVERSIBLE DECREASES IN GROWTH VELOCITY IN THE PHASE 2 FIREFLY-1 TRIAL
Kline, Cassie
Waanders, Angela J.
Ziegler, David S.
Kilburn, Lindsay B.
Nysom, Karsten
van der Lugt, Jasper
Hassall, Timothy E.
Gerber, Nicolas U.
Segal, Devorah
Larouche, Valerie
Khuong-Quang, Dong-Anh
Hansford, Jordan R.
Leary, Sarah E. S.
Driever, Pablo Hernaiz
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[10] The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (vol 30, pg 207, 2024)
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van der Lugt, Jasper
Leary, Sarah E. S.
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Ziegler, David S.
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Baxter, Patricia A.
Kang, Hyoung Jin
Hassall, Timothy E.
Han, Jung Woo
Hargrave, Darren
Franson, Andrea T.
Oren, Michal Yalon
Toledano, Helen
Larouche, Valerie
Kline, Cassie
Abdelbaki, Mohamed S.
Jabado, Nada
Gottardo, Nicholas G.
Gerber, Nicolas U.
Whipple, Nicholas S.
Segal, Devorah
Chi, Susan N.
Oren, Liat
Tan, Enrica E. K.
Mueller, Sabine
Cornelio, Izzy
McLeod, Lisa
Zhao, Xin
Walter, Ashley
Da Costa, Daniel
Manley, Peter
Blackman, Samuel C.
Packer, Roger J.
Nysom, Karsten
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