Effectiveness of Platelet-Rich Plasma for COVID-19-Related Olfactory Dysfunction: A Controlled Study

被引:12
|
作者
Lechien, Jerome R. R. [1 ,2 ,3 ,4 ]
Saussez, Sven [2 ,4 ]
Vaira, Luigi A. A. [5 ]
De Riu, Giacomo [5 ]
Boscolo-Rizzo, Paolo [6 ]
Tirelli, Giancarlo [6 ]
Michel, Justin [7 ]
Radulesco, Thomas [7 ]
机构
[1] Elsan, Dept Otolaryngol, Polyclin Poitiers, Poitiers, France
[2] Univ Mons UMons, UMONS Res Inst Hlth Sci & Technol, Fac Med, Dept Human Anat & Expt Oncol, Mons, Belgium
[3] Paris Saclay Univ, Univ Versailles St Quentin En Yvelines, Dept Otolaryngol Head & Neck Surg, Foch Hosp,Sch Med,UFR Simone Veil, Paris, France
[4] CHU St Pierre, Dept Otorhinolaryngol & Head & Neck Surg, Brussels, Belgium
[5] Univ Sassari, Dept Med Surg & Pharm, Maxillofacial Surg Operat Unit, Sassari, Italy
[6] Univ Trieste, Dept Med Surg & Hlth Sci, Sect Otolaryngol, Trieste, Italy
[7] Aix Marseille Univ, Concept Univ Hosp, AP HM, Dept Otorhinolaryngol & Head & Neck Surg,IUSTI,CNR, Marseille, France
关键词
anosmia; COVID-19; hyposmia; olfactory; otolaryngology; platelet-rich plasma; recovery; rhinology; SARS-CoV-2; smell; NORMATIVE DATA; PREVALENCE;
D O I
10.1002/ohn.460
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
ObjectiveTo investigate the effectiveness of platelet-rich plasma (PRP) injection into the olfactory clefts of coronavirus disease 2019 (COVID-19) patients with persistent olfactory dysfunction (OD). Study DesignControlled study. SettingMulticenter study. MethodsFrom March 2022 to November 2022, COVID-19 patients with persistent OD were recruited from three European hospitals to undergo PRP injections into the olfactory clefts. Olfactory function was evaluated at baseline and 10 weeks postinjection with the Olfactory Disorder Questionnaire (ODQ) and threshold, discrimination, and identification (TDI) test. Data were compared with a control group of untreated patients. ResultsEighty-one patients who underwent PRP injection and 78 controls were included. Sixty-five PRP patients (80.3%) experienced subjective smell improvement after a mean duration of 3.4 & PLUSMN; 1.9 weeks. The parosmia, life quality statement, and ODQ sub- and total scores significantly decreased from pre- to 10-week postinjection in the PRP group. The TDI sub- and total scores significantly increased 10 weeks postinjection. In controls, the ODQ score did not change over time, while the discrimination, identification, and total TDI scores significantly increase after 10 weeks of follow-up. The 10-week TDI and ODQ scores were significantly better in the PRP group compared with the controls. ConclusionPatients who underwent PRP injection reported better 10-week subjective and objective smell outcomes than controls. Future randomized-controlled studies using saline injection into the olfactory cleft of controls are needed to determine the superiority of PRP over placebo.
引用
收藏
页码:84 / 91
页数:8
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