Copper-catalyzed Markovnikov hydroboration of aliphatic terminal alkenes using carbonyl as a weak directing group

Herein, we reported a copper-catalyzed carbonyl-assisted hydroboration of terminal aliphatic alkenes with Markovnikov regioselectivity, employing easily available and stable B(2)Pin(2) as the boron source. This reaction proceeded smoothly with exclusive Markovnikov regioselectivity and provided facile access to a series of branched secondary alkyl boronic esters in moderate to excellent yields. The hydrogen source stemmed from the solvent, which was illustrated by the deuterium experiments.