Dinuclear Zinc-Catalyzed Asymmetric Desymmetrization of Cyclopentendiones: Access to Functional Cyclopentanediones Bearing an All-carbon Quaternary Stereocenter

被引：1

作者：

Du, Si-Si ^{[1
]}

Zhai, Ying-Hui ^{[1
]}

Zhang, Cui ^{[1
]}

Wang, Min-Can ^{[1
]}

Jia, Shi-Kun ^{[1
]}

Mei, Guang-Jian ^{[1
]}

Hua, Yuan-Zhao ^{[1
]}

机构：

[1] Zhengzhou Univ, Inst Green Catalysis, Coll Chem, 100 Sci Rd, Zhengzhou City 450000, Henan Province, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2023年 / 18卷 / 18期

关键词：

cyclopentendiones; desymmetrization; dinuclear zinc catalyst; MANNICH-TYPE REACTION; ENANTIOSELECTIVE DESYMMETRIZATION; MESO-EPOXIDES; CONSTRUCTION; CYCLOPENTENEDIONES; DESYMMETRISATION; HYDROXYKETONES; ARYLATION; ADDITIONS; AMINES;

D O I：

10.1002/asia.202300591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The success in the identification of the two enantioisomeric surfaces of electrophiles by dinuclear zinc catalysts is disclosed. This protocol realizes a dinuclear zinc-cocatalyzed desymmetrization of cyclopentendiones using & alpha;-hydroxy aryl ketones as nucleophiles through Michael addition reaction. Under mild conditions, a series of functional cyclopentanediones bearing multiple stereogenic centers including an all-carbon quaternary stereocenter, were obtained in moderate to good yields with excellent stereoselectivities.

引用

页数：5

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