Adverse Effects of Non-Metallic Nanoparticles in the Central Nervous System

被引:3
|
作者
Sikorska, Katarzyna [1 ]
Sawicki, Krzysztof [2 ]
Czajka, Magdalena [2 ]
Kapka-Skrzypczak, Lucyna [2 ,3 ]
Kruszewski, Marcin [1 ,2 ]
Brzoska, Kamil [1 ]
机构
[1] Inst Nucl Chem & Technol, Ctr Radiobiol & Biol Dosimetry, Dorodna 16, PL-03195 Warsaw, Poland
[2] Inst Rural Hlth, Dept Mol Biol & Translat Res, Jaczewskiego 2, PL-20090 Lublin, Poland
[3] Calisia Univ, World Inst Family Hlth, Nowy Swiat 4, PL-62800 Kalisz, Poland
关键词
nanoparticles; central nervous system; human health; neurodegenerative disease; BLOOD-BRAIN-BARRIER; CURCUMIN-LOADED NANOPARTICLES; SOLID LIPID NANOPARTICLES; PEG-PLGA NANOPARTICLES; TARGETED DRUG-DELIVERY; IN-VITRO CYTOTOXICITY; CARBON NANOTUBES; SILICA NANOPARTICLES; OXIDATIVE STRESS; POLYAMIDOAMINE DENDRIMERS;
D O I
10.3390/ma16237264
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The interest in nanoparticles (NPs) and their effects on living organisms has been continuously growing in the last decades. A special interest is focused on the effects of NPs on the central nervous system (CNS), which seems to be the most vulnerable to their adverse effects. Non-metallic NPs seem to be less toxic than metallic ones; thus, the application of non-metallic NPs in medicine and industry is growing very fast. Hence, a closer look at the impact of non-metallic NPs on neural tissue is necessary, especially in the context of the increasing prevalence of neurodegenerative diseases. In this review, we summarize the current knowledge of the in vitro and in vivo neurotoxicity of non-metallic NPs, as well as the mechanisms associated with negative or positive effects of non-metallic NPs on the CNS.
引用
收藏
页数:39
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