BATHYMODIOLAMIDES C, D, AND E, NECROSIS INDUCERS FROM A DEEP-SEA HYDROTHERMAL VENT INVERTEBRATE MUSSEL, BATHYMODIOLUS AZORICUS

被引：1
|
作者：
Andrianasolo, Eric H. [1 ,2 ]
Haramaty, Liti [3 ]
McPhail, Kerry L. [4 ]
Lutz, Richard A. [3 ]
机构：
[1] Ctr Natl Rech Ind & Technol CNRIT, 38,rue Rasamimanana, Antananarivo 101, Madagascar
[2] Univ Waterloo, Dept Biol, 200 Univ Ave W, Waterloo, ON N2L 3G1, Canada
[3] Rutgers State Univ, Dept Marine & Coastal Sci, 71 Dudley Rd, New Brunswick, NJ 08901 USA
[4] Oregon State Univ, Dept Pharmaceut Sci, 103 SW Mem Pl, Corvallis, OR 97331 USA
来源：
JOURNAL OF SHELLFISH RESEARCH | 2023年 / 42卷 / 02期
关键词：
Ceramide; necrosis inducer; anticancer agent; marine biotechnology; marine hydrothermal vent mussel; Bathymodiolus azoricus; METABOLITES; NECROPTOSIS; CERAMIDE;
D O I：
10.2983/035.042.0201
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Three ceramides with intriguing structural features, bathymodiolamides C (1), D (2), and E (3), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus azoricus that inhabits vent environments along the Mid-Atlantic Ridge. The molecular structures of these compounds were elucidated using a combination of Nuclear Magnetic Resonance spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed by Lactate Dehydrogenase assay for necrosis induction and the patented ApopScreen cell-based screen for apoptosis-induction and potential anticancer activity. This represents a second report of ceramide natural products from B. azoricus.
引用
收藏
页码：177 / 197
页数：21
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