Acupoint catgut embedding for simple obesity in animal studies: a systematic review and Meta-analysis

OBJECTIVE: To assess the efficacy of acupoint catgut embedding (ACE) for simple obesity in preclinical animal experiments. METHODS: We searched the following 14 electronic databases: PubMed, Cochrane Library, EMBASE, Oriental Medicine Advanced Searching Integrated System, KoreaMed, Korean Studies Information Service System, Science-on, Research Information Sharing Service, Korea Citation Index, Korea Traditional Knowledge Portal, China Network Knowledge Infrastructure Database, Wanfang Database, Chinese Science and Technology Journal Database, and Chinese Biology Medicine Database, from inception to November 2021 without language limitation. The assessment was performed according to the guidelines of Animal Research: Reporting of in vivo experiments; and Metaanalysis was performed using Reviewer Manager 5.4.1 software. RESULTS: Twenty-four studies involving 813 animals were selected. Meta-analysis showed that ACE was beneficial for weight control [n = 40, MD = -50.63, 95% CI (-57.59, -43.67), P < 0.000 01, I-2 = 0%] and reduced the Lee index [n = 40, MD = -18.79, 95% CI (-20.01, -17.57), P < 0.000 01, I-2 = 0%]. However, when efficacy of ACE was compared with that of manual acupuncture, electroacupuncture, or oilistat therapy, statistical difference was not observed between the two groups. CONCLUSIONS: This systematic review suggests that ACE may be efficacious in treating obesity. Moreover, the analyses highlighted the necessity to perform welldesigned, higher-quality experiments. (c) 2023 JTCM. All rights reserved.