DIPEA-Assisted Efficient One-Pot Three-Component Synthesis of Novel β-Carboline Tethered Pyran Derivatives

被引：1

作者：

Banyal, Naveen ^{[1
,2
]}

Malakar, Chandi C. ^{[3
]}

Kumar, Rakesh ^{[1
]}

Singh, Virender ^{[2
]}

机构：

[1] Dr BR Ambedkar Natl Inst Technol, Dept Chem, Jalandhar 144027, Punjab, India

[2] Cent Univ Punjab, Dept Chem, Bathinda 151004, Punjab, India

[3] Natl Inst Technol, Dept Chem, Imphal 795004, India

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 03期

关键词：

beta-Carboline; Kumujian C; Metal-free; Multicomponenty; Pyran Synthesis; METAL-FREE APPROACH; BIOLOGICAL EVALUATION; FACILE SYNTHESIS; IN-VITRO; ANALOGS; INHIBITOR; DISCOVERY; ALKALOIDS; BROVINCAMINE; DIVERSITY;

D O I：

10.1002/slct.202304751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A potential DIPEA-assisted approach has been unfolded for the synthesis of novel beta-carboline tethered-4H-pyran derivatives via one-pot condensation of 1-formyl-9H-beta-carbolines, beta-keto esters and malononitrile in ethanol at ambient temperature. A library of 28 new beta-carboline tethered 4H-pyran derivatives has been developed. The significant features of the present strategy include high efficiency, excellent yield, inexpensive catalyst, mild reaction conditions, multicomponent character of reaction and simple purification procedure.

引用

页数：10

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