DIPEA-Assisted Efficient One-Pot Three-Component Synthesis of Novel β-Carboline Tethered Pyran Derivatives

被引：1

作者：

Banyal, Naveen ^{[1
,2
]}

Malakar, Chandi C. ^{[3
]}

Kumar, Rakesh ^{[1
]}

Singh, Virender ^{[2
]}

机构：

[1] Dr BR Ambedkar Natl Inst Technol, Dept Chem, Jalandhar 144027, Punjab, India

[2] Cent Univ Punjab, Dept Chem, Bathinda 151004, Punjab, India

[3] Natl Inst Technol, Dept Chem, Imphal 795004, India

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 03期

关键词：

beta-Carboline; Kumujian C; Metal-free; Multicomponenty; Pyran Synthesis; METAL-FREE APPROACH; BIOLOGICAL EVALUATION; FACILE SYNTHESIS; IN-VITRO; ANALOGS; INHIBITOR; DISCOVERY; ALKALOIDS; BROVINCAMINE; DIVERSITY;

D O I：

10.1002/slct.202304751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A potential DIPEA-assisted approach has been unfolded for the synthesis of novel beta-carboline tethered-4H-pyran derivatives via one-pot condensation of 1-formyl-9H-beta-carbolines, beta-keto esters and malononitrile in ethanol at ambient temperature. A library of 28 new beta-carboline tethered 4H-pyran derivatives has been developed. The significant features of the present strategy include high efficiency, excellent yield, inexpensive catalyst, mild reaction conditions, multicomponent character of reaction and simple purification procedure.

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页数：10

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