Recent Progress in the Construction of Chiral 3-Substituted Indoles by Asymmetric Friedel-Crafts Reactions

被引：0

作者：

Liu Tiantian ^{[1
]}

Duan Xinhong ^{[1
]}

机构：

[1] Beijing Forestry Univ, Coll Sci, Beijing 100083, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 11期

关键词：

chiral catalyst; asymmetric Friedel-Crafts alkylation; C(3)-substituted chiral indole; chiral induction; DIELS-ALDER REACTION; ENANTIOSELECTIVE SYNTHESIS; PHOSPHORIC-ACID; MICHAEL ADDITION; ALKYLATION REACTIONS; HETEROAROMATIC-COMPOUNDS; HIGHLY EFFICIENT; DIRECT ARYLATION; BRONSTED ACIDS; CARBONYL-ENE;

D O I：

10.6023/cjoc202303010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral C(3)-functionalized indoles have received much attention as strategic building blocks for the synthesis of many natural products and bioactive compounds. Particularly in the past twenty years, application of chiral metal complexes and small-molecule organocatalysts for the asymmetric Friedel-Crafts C(3)-alkylations of indoles has become a hot topic in the organic field. Applications of asymmetric Friedel-Crafts reactions in the synthesis of C(3)-substituted indoles are reviewed according to the catalysts that promoting reaction. Moreover, future perspectives are also presented.

引用

页码：3695 / 3712

页数：18

共 143 条

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