Polyarylether-based COFs coordinated by Tb3+ for the fluorescent detection of anthrax-biomarker dipicolinic acid

被引：10

作者：

Liu, Yinsheng ^{[1
]}

Wang, Mingyue ^{[1
]}

Hui, Yinfei ^{[1
]}

Sun, Lei ^{[1
]}

Hao, Yanrui ^{[1
]}

Ren, Henlong ^{[1
]}

Guo, Hao ^{[1
]}

Yang, Wu ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Minist Educ,Gansu Int Sci & Technol Cooperat Base, Key Lab Ecofunct Polymer Mat,Key Lab Water Secur, Lanzhou 730070, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2024年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

COVALENT ORGANIC FRAMEWORK; NANOPROBE; DIAGNOSIS; PLATFORM;

D O I：

10.1039/d3tb02070c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this study, a rare-earth hybrid luminescent material (lanthanide@COF) was constructed for the detection of a biomarker for anthrax (dipicolinic acid, DPA). JCU-505-COOH was prepared by the hydrolysis of the cyano group in JCU-505 via a post-synthetic modification strategy, then the carboxyl groups in JCU-505-COOH coordinated with Tb3+ ions, similar to pincer vising nut. The prepared Tb3+@JCU-505-COOH exhibited a turn-on response toward DPA, which allowed the lanthanide@COF to serve as a fluorescence sensor with excellent selectivity and high sensitivity (binding constant K-a = 3.66 x 10(3)). The fluorescent probe showed satisfactory performance for the determination of DPA in saliva and urine with a detection limit of 0.6 mu M. Moreover, we established a facile point-of-care testing (POCT) using the Tb3+@JCU-505-COOH-based fluorescent test paper together with a smartphone for the initial diagnosis of anthrax. As expected, Tb3+@JCU-505-COOH showed great potential for the rapid screening of anthrax due to low cost, simple operation, and wide applicability.

引用

页码：466 / 474

页数：9