Diffractive micro-lens array (DLA) for uniform and selective picosecond laser treatment

Picosecond Nd:YAG lasers using diffractive optical elements (DOE) and microlens arrays (MLA) have widely been used in dermatology for the treatment of pigmented lesions and skin rejuvenation. This study designed and developed a new optical element of diffractive micro-lens array (DLA) by combing the features of DOE and MLA in order to achieve uniform and selective laser treatment. Both optical simulation and beam profile measurement demonstrated that DLA created a square macro-beam consisting of multiple micro-beams in a uniform distribution. Histological analysis confirmed that the DLA-assisted laser treatment generated micro-injuries at various skin depths from the epidermal layer to the deep dermal layer (up to 1200 mu m) by adjusting the focal depths while DOE showed shallow penetration depths and MLA created non-uniform micro-injury zones. The DLA-assisted picosecond Nd:YAG laser irradiation can provide a potential benefit for pigment removal and skin rejuvenation via uniform and selective laser treatment.