Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2

被引：1
|
作者：
Chen, Yu-San [1 ]
Lee, Chang-Ye [1 ]
Wu, Chi-Chien [1 ]
Kao, Pei-Lun [2 ]
Chen, Tai-An [1 ]
Huang, Yahui [1 ]
Chung, Wen-Bin [3 ]
Kuo, Tsun-Yung [2 ]
Chen, Charles [1 ,4 ]
机构：
[1] Schweitzer Biotech Co Ltd, Taipei City, Taiwan
[2] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Yilan Cty, Taiwan
[3] Natl Pingtung Univ Sci & Technol, Res Ctr Anim Biol, Pingtung Cty, Taiwan
[4] Temple Univ, Philadelphia, PA 19122 USA
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
PCV2; VACCINES; CHALLENGE; MUTANT;
D O I：
10.1038/s41598-024-53624-w
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2) are two of the most devastating and economically significant pathogens affecting pig populations worldwide. Administration of a combination of vaccines against swine pathogens has been demonstrated to be as efficacious as the administration of single vaccines. In this study, we developed and tested a novel bivalent subunit vaccine against CSFV and PCV2. The safety and efficacy of this vaccine were demonstrated in mice and specific pathogen-free (SPF) piglets. In addition to investigating the serological responses after immunization, challenge studies with both viruses were also conducted. The results showed that this CSFV/PCV2 bivalent vaccine elicited a high level of neutralizing antibodies against both viruses and provided protection in challenge studies. In conclusion, the CSFV/PCV2 bivalent vaccine is safe and effective against CSFV or PCV2 challenge.
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页数：10
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