Acerola fruit by-product alleviates lipid, glucose, and inflammatory changes in the enterohepatic axis of rats fed a high-fat diet

被引：13
|
作者：
Batista, Kamila Sabino [1 ,2 ]
Soares, Nais Lira [1 ,2 ]
Dorand, Victor Augusto Mathias [1 ,2 ]
Alves, Adriano Francisco [3 ]
Lima, Marcos dos Santos [4 ]
Pereira, Ramon de Alencar [5 ]
de Souza, Evandro Leite [2 ,6 ]
Magnani, Marciane [2 ,7 ]
Persuhn, Darlene Camati [2 ,8 ]
Aquino, Jailane de Souza [1 ,2 ,9 ,10 ]
机构：
[1] Fed Univ Paraiba UFPB, Dept Nutr, Expt Nutr Lab, Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba, Post Grad Program Nutr Sci, Joao Pessoa, Paraiba, Brazil
[3] Fed Univ Paraiba UFPB, Dept Physiol & Pathol, Lab Pathol, Joao Pessoa, Paraiba, Brazil
[4] Fed Inst Sertao Pernambuco IFPE Sertao, Dept Food Technol, Food Technol Lab, Petrolina, PE, Brazil
[5] Fed Univ Minas Gerais UFMG, Dept Pathol, Lab Leishmaniasis Pathol, Belo Horizonte, MG, Brazil
[6] Univ Fed Paraiba, Hlth Sci Ctr, Dept Nutr, Lab Food Microbiol, Joao Pessoa, Brazil
[7] Fed Univ Paraiba UFPB, Dept Food Engn, Lab Microbial Proc Food, Joao Pessoa, Paraiba, Brazil
[8] Univ Fed Paraiba, Dept Mol Biol, Joao Pessoa, Brazil
[9] Fed Univ Paraiba UFPB, Dept Nutr, Expt Nutr Lab, BR-58051900 Joao Pessoa, PB, Brazil
[10] Fed Univ Paraiba UFPB, Post Grad Program Nutr Sci, BR-58051900 Joao Pessoa, PB, Brazil
来源：
FOOD CHEMISTRY | 2023年 / 403卷
关键词：
Fruit by-product; Glucose; Lipids; Macrophages; Malpighia emarginata; Organic acids; METHOD VALIDATION; GUT MICROBIOTA; METABOLISM; ACIDS; FENOFIBRATE; FLAVONOIDS; OBESITY; JUICES; GRAPE;
D O I：
10.1016/j.foodchem.2022.134322
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Acerola (Malpighia emarginata) by-product (ABP) has various bioactive compounds with hypoglycaemic, anti-oxidant and anti-inflammatory activity. The ABP effects on the biochemical changes in the enterohepatic axis caused by a high-fat diet (HFD) remains unclear. This study assessed whether the ABP or fenofibrate adminis-tration for 28 days interferes in lipid, glucose, or inflammatory changes in the enterohepatic axis of rats fed HFD. ABP induced in the rats fed HFD a reduction in body weight, serum lipids, blood glucose, and liver fat accu-mulation; increased insulin tolerance, and faecal bile acid excretion; regulated organic acid synthesis, faecal and colonic microbial growth; reduced M1 macrophage and increased M2 macrophage infiltration in the colon and liver, respectively. The fenofibrate did not improve the lipid or glucose alterations in enterohepatic axis of rats fed HFD. ABP has functional/nutraceutical potential in treating HFD-induced metabolic disorders with beneficial effects on lipid and glucose metabolism, and reduction of inflammation.
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页数：12
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