Chemical Modification of Polysaccharides: A Review of Synthetic Approaches, Biological Activity and the Structure-Activity Relationship

被引：37
|
作者：
Liu, Tianbo [1 ]
Ren, Qianqian [1 ]
Wang, Shuang [1 ]
Gao, Jianing [1 ]
Shen, Congcong [1 ]
Zhang, Shengyu [1 ]
Wang, Yanhong [1 ,2 ]
Guan, Feng [1 ,2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Sch Pharm, 24 Heping Rd, Harbin 150040, Peoples R China
[2] Heilongjiang Univ Chinese Med, Minist Educ, Key Lab Basic & Applicat Res Beiyao, 24 Heping Rd, Harbin 150040, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 16期
基金：
中国国家自然科学基金;
关键词：
polysaccharide; chemical modification; biological activity; SULFATED MODIFICATION; CYCLOCARYA-PALIURUS; SELENYLATION MODIFICATION; ANTIOXIDANT ACTIVITIES; SELECTIVE SULFATION; ANTICOAGULANT; BIOACTIVITIES; PURIFICATION; DERIVATIVES; MECHANISM;
D O I：
10.3390/molecules28166073
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural polysaccharides are macromolecular substances with great potential owing to their wide biological activity and low toxicity. However, not all polysaccharides have significant pharmacodynamic activity; hence, appropriate chemical modification methods can be selected according to the unique structural characteristics of polysaccharides to assist in enhancing and promoting the presentation of their biological activities. This review summarizes research progress on modified polysaccharides, including common chemical modification methods, the change in biological activity following modification, and the factors affecting the biological activity of chemically modified polysaccharides. At the same time, the difficulties and challenges associated with the structural modification of natural polysaccharides are also outlined in this review. Thus, research on polysaccharide structure modification is critical for improving the development and utilization of sugar products.
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收藏
页数：23
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