A possible mechanism of neural read-out from a molecular engram

被引：2

作者：

Mollon, J. D. ^{[1
]}

Danilova, M. V. ^{[1
,2
]}

Zhuravlev, A. V. ^{[2
]}

机构：

[1] Univ Cambridge, Dept Psychol, Downing St, Cambridge CB2 3EB, England

[2] Pavlov Inst Physiol, nab Makarova 6, St Petersburg 199034, Russia

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2023年 / 200卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Memory; Retrieval; Engram; Nucleic acid; Nanopore; DNA; RNA; DNA; STORAGE; CELLS;

D O I：

10.1016/j.nlm.2023.107748

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

What is the physical basis of declarative memory? The predominant view holds that stored information is embedded in the structure of a neural net, that is, in the signs and weights of its synaptic connections. An alternative possibility is that storage and processing are separated, and that the engram is encoded chemically, most probably in the sequence of a nucleic acid. One deterrent to adoption of the latter hypothesis has been the difficulty of envisaging how neural actively could be converted to and from a molecular code. Our purpose here is limited to suggesting how a molecular sequence could be read out from nucleic acid to neural activity by means of nanopores.

引用

页数：5

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