Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp 3 )-H Amidation for the Synthesis of Isoindolinones

被引：0
|
作者：
Yang, Darun [1 ]
Xu, Hongyan [1 ]
Huang, Decai [1 ]
Zhao, Huaiqing [1 ]
机构：
[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2023年 / 55卷 / 03期
关键词：
rhodium(III) catalyst; C(sp (3) )-H amidation; isoindolinones; N-substituted benzamides; synthetic methods; RH-CATALYZED ANNULATIONS; H BOND ACTIVATION; N-METHOXYBENZAMIDES; C-C; FUNCTIONALIZATION; CARBONYLATION; PHTHALIMIDES; CYCLIZATION; BENZAMIDES;
D O I：
10.1055/a-1954-4920
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of N-unprotected isoindolinones via rhodi-um(III)-catalyzed intramolecular C(sp(3))-H amidation of various 2-meth-yl-N-substituted benzamides is developed. This protocol employs a free amino acid L-alanine as a ligand, which could significantly increase the reactivity of rhodium catalyst.
引用
收藏
页码：481 / 488
页数：8
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