[(SIPr)Ag(CF2H)]: A Shelf-Stable, Versatile Difluoromethylation Reagent

被引：4

作者：

Zhao, Haiwei ^{[1
]}

Gu, Yang ^{[1
]}

Shen, Qilong ^{[1
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHEMICAL RECORD | 2023年 / 23卷 / 09期

基金：

中国国家自然科学基金;

关键词：

fluorine; difluoromethyl; silver; reagent; nucleophilic; PALLADIUM-CATALYZED DIFLUOROMETHYLATION; COPPER-MEDIATED DIFLUOROMETHYLATION; CARBON NUCLEOPHILES; RECENT PROGRESS; ARYL CHLORIDES; DIFLUOROMETHYLTHIOLATION; BROMIDES; IODIDES; HALIDES; REACTIVITY;

D O I：

10.1002/tcr.202300124

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to its unique physical and electrophilic properties, the difluoromethyl group (-CF2H) has been playing an irreplaceable role in the field of pharmaceutical and agrochemical industry. Methods that could efficiently incorporate the difluoromethyl group into the target molecules are increasing in the recent years. Developing a stable and efficient difluoromethylating reagent is thus highly attractive. In this review, we describe the development of a nucleophilic difluoromethylation reagent [(SIPr)Ag(CF2H)], including its elemental reaction, difluoromethylation reaction with different types of electrophiles, and its application in the synthesis of a nucleophilic and an electrophilic difluoromethylthiolating reagent.

引用

页数：15

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