Direct synthesis of alkylated 4-hydroxycoumarin derivatives via a cascade Cu-catalyzed dehydrogenation/conjugate addition sequence

被引：9

作者：

Chen, Zhiliang ^{[1
,2
]}

Li, Hongyi ^{[2
]}

Liao, Yanjing ^{[2
]}

Wang, Mengqi ^{[1
,2
]}

Su, Weiping ^{[2
]}

机构：

[1] Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China

[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fujian Sci & Technol Innovat Lab Optoelect Informa, Fuzhou 350002, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 44期

基金：

中国国家自然科学基金;

关键词：

Compendex;

D O I：

10.1039/d3cc01960h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives via a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance, easy scale-up, and a broad substrate scope including bioactive molecules. More importantly, a series of marketed drugs, such as warfarin, acenocoumarol, coumachlor, and coumafuryl, can be obtained by this method.

引用

页码：6686 / 6689

页数：4

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