The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer's Disease

被引:5
|
作者
Ferrisi, Rebecca [1 ,2 ]
Gado, Francesca [2 ]
Ricardi, Caterina [3 ]
Polini, Beatrice [3 ]
Manera, Clementina [1 ]
Chiellini, Grazia [3 ]
机构
[1] Univ Pisa, Dept Pharm, I-56126 Pisa, Italy
[2] Univ Milan, Dept Pharmaceut Sci, I-20133 Milan, Italy
[3] Univ Pisa, Dept Pathol, I-56126 Pisa, Italy
关键词
cannabinoid receptors; microglia; neuroinflammation; CENTRAL-NERVOUS-SYSTEM; CB2; RECEPTORS; MOLECULAR CHARACTERIZATION; ENDOCANNABINOID SYSTEM; FUNCTIONAL EXPRESSION; RAT MODEL; BRAIN; CELLS; LIGANDS; IDENTIFICATION;
D O I
10.3390/jcm12237201
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Alzheimer's disease (AD) is characterized by massive neuronal death, brain atrophy, and loss of neurons and synapses, which all lead to a progressive cognitive decline. Neuroinflammation has been recently identified as one of the main causes of AD progression, and microglia cells are considered to have a central role in this process. Growing evidence suggests that cannabinoids may be used as preventive treatment for AD. An altered expression of the endocannabinoids (eCBs) and their receptors (CBRs) is reported in several neurodegenerative disorders, including AD. Moreover, the modulation of CBRs demonstrated neuroprotective effects in reducing aggregated protein deposition, suggesting the therapeutic potential of natural and synthetic CBR ligands in the treatment of neurodegenerative proteinopathies. Here, we review the current knowledge regarding the involvement of CBRs in the modulation of microglia activation phenotypes, highlighting the role of neuroinflammation in the pathogenesis of neurodegenerative diseases, like AD. We also provide an overview of recently developed candidate drugs targeting CBRs that may afford a new innovative strategy for the treatment and management of AD.
引用
收藏
页数:21
相关论文
共 50 条
  • [21] The pathophysiology of Alzheimer's disease
    Roberts, GW
    BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 : P380 - P380
  • [22] Pathophysiology of Alzheimer's Disease
    Yarns, Brandon C.
    Holiday, Kelsey A.
    Carlson, David M.
    Cosgrove, Coleman K.
    Melrose, Rebecca J.
    PSYCHIATRIC CLINICS OF NORTH AMERICA, 2022, 45 (04) : 663 - 676
  • [23] Pathophysiology of Alzheimer's disease
    Imbimbo, BP
    Lombard, J
    Pomara, N
    NEUROIMAGING CLINICS OF NORTH AMERICA, 2005, 15 (04) : 727 - +
  • [24] Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex
    Lee, Jasinda H.
    Agacinski, Grzegorz
    Williams, Jonathan H.
    Wilcock, Gordon K.
    Esiri, Margaret M.
    Francis, Paul T.
    Wong, Peter T-H
    Chen, Christopher P.
    Lai, Mitchell K.
    NEUROCHEMISTRY INTERNATIONAL, 2010, 57 (08) : 985 - 989
  • [25] Untangling the relationship between microglia and tau in Alzheimer's disease
    Rossano, Samantha M.
    Kreisl, William Charles
    TRENDS IN NEUROSCIENCES, 2021, 44 (12) : 927 - 929
  • [26] Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age
    Chen, Yanting
    Hong, Tingting
    Chen, Feng
    Sun, Yuanhong
    Wang, Yan
    Cui, Lili
    FRONTIERS IN AGING NEUROSCIENCE, 2021, 13
  • [27] Microglia and microglial-based receptors in the pathogenesis and treatment of Alzheimer?s disease
    Wang, Zhiyu
    Weaver, Donald F.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 110
  • [28] The Link Between Matrix Metalloproteinases and Alzheimer's Disease Pathophysiology
    Radosinska, Dominika
    Radosinska, Jana
    MOLECULAR NEUROBIOLOGY, 2025, 62 (01) : 885 - 899
  • [29] Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer's Disease
    Takata, Kazuyuki
    Kimura, Hiroyuki
    Yanagisawa, Daijiro
    Harada, Koki
    Nishimura, Kaneyasu
    Kitamura, Yoshihisa
    Shimohama, Shun
    Tooyama, Ikuo
    MOLECULES, 2022, 27 (09):
  • [30] The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease
    Jehle, Aileen
    Garaschuk, Olga
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)