Relationship Between Short-chain Fatty Acids and Parkinson's Disease: A Review from Pathology to Clinic

被引：18
|
作者：
Duan, Wen-Xiang [1 ,2 ]
Wang, Fen [1 ,2 ,4 ,5 ]
Liu, Jun-Yi [3 ]
Liu, Chun-Feng [1 ,2 ,4 ,5 ]
机构：
[1] Soochow Univ, Affiliated Hosp 2, Dept Neurol, Suzhou 215004, Peoples R China
[2] Soochow Univ, Affiliated Hosp 2, Clin Res Ctr Neurol Dis, Suzhou 215004, Peoples R China
[3] Soochow Univ, Dushu Lake Hosp, Dept Neurol, Suzhou 215125, Peoples R China
[4] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China
[5] Soochow Univ, Inst Neurosci, Suzhou 215123, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2024年 / 40卷 / 04期
关键词：
Parkinson's disease; Short-chain fatty acids; Microbial metabolites; Brain-gut-microbiota axis; PROTECTS DOPAMINERGIC-NEURONS; BRAIN-BARRIER PERMEABILITY; GLUCAGON-LIKE PEPTIDE-1; SODIUM-BUTYRATE; ALPHA-SYNUCLEIN; GUT MICROBIOTA; MONOCARBOXYLATE TRANSPORTERS; INDUCED NEUROTOXICITY; COLONIC INFLAMMATION; METABOLITE BUTYRATE;
D O I：
10.1007/s12264-023-01123-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parkinson's disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of & alpha;-synuclein (& alpha;-syn) in Lewy bodies and neurites, and massive loss of midbrain dopamine neurons. Increasing evidence suggests that gut microbiota and microbial metabolites are involved in the development of PD. Among these, short-chain fatty acids (SCFAs), the most abundant microbial metabolites, have been proven to play a key role in brain-gut communication. In this review, we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor symptoms. Future research should focus on further elucidating the role of SCFAs in neuroinflammation, as well as developing novel strategies employing SCFAs and their derivatives to treat PD.
引用
收藏
页码：500 / 516
页数：17
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