Improving solubility of poorly water-soluble drugs by protein-based strategy: A review

被引：39
|
作者：
Liu, Xiaowen [1 ,2 ]
Zhao, Limin [1 ,2 ]
Wu, Baojian [3 ]
Chen, Fener [1 ,2 ]
机构：
[1] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China
[2] Shanghai Engn Res Ctr Ind Asymmetr Catalysis Chira, 220 Handan Rd, Shanghai 200433, Peoples R China
[3] Guangzhou Univ Chinese Med, Inst Mol Rhythm & Metab, Guangzhou 510006, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2023年 / 634卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Poorly water-soluble drugs; Bioavailability; Protein; Water solubility; Solubility enhancement; AMORPHOUS SOLID DISPERSIONS; SERUM-ALBUMIN NANOPARTICLES; IN-VIVO; GLIADIN NANOPARTICLES; ORAL BIOAVAILABILITY; ANTIOXIDANT ACTIVITY; ZEIN NANOPARTICLES; FORMULATION DESIGN; PHENOLIC-COMPOUNDS; DELIVERY-SYSTEMS;
D O I：
10.1016/j.ijpharm.2023.122704
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poorly water-soluble drugs are frequently encountered and present a most challengeable difficulty in pharma-ceutical development. Poor solubility of drugs can lead to suboptimal bioavailability and therapeutic efficiency. Increasing efforts have been contributed to improve the solubility of poorly water-soluble drugs for better pharmacokinetics and pharmacodynamics. Among various solubility enhancement technologies, protein-based strategy to address poorly water-soluble drugs issues has special interests for natural advantages including versatile interactions between proteins and hydrophobic drugs, biocompatibility, biodegradation, and metabo-lization of proteins. The protein-drug formulations could be formed by covalent conjugations or noncovalent interactions to facilitate solubility of poorly water-soluble drugs. This review is to summarize the advances using proteins including plant proteins, mammalian proteins, and recombinant proteins, to enhance water solubility of poorly water-soluble drugs.
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页数：15
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