Recent advances and applications in high-throughput continuous flow

被引:7
|
作者
Yu, Jiaping [1 ]
Liu, Jiaying [4 ]
Li, Chaoyi [1 ]
Huang, Junrong [1 ]
Zhu, Yuxiang [3 ]
You, Hengzhi [1 ,2 ]
机构
[1] Harbin Inst Technol Shenzhen, Sch Sci, Shenzhen 518055, Peoples R China
[2] Harbin Inst Technol Shenzhen, Green Pharmaceut Engn Res Ctr, Shenzhen 518055, Peoples R China
[3] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen Campus, Shenzhen 518107, Peoples R China
[4] Heilongjiang Acad Sci, Inst Adv Technol, Harbin 150000, Peoples R China
基金
中国国家自然科学基金;
关键词
MEDICINAL CHEMISTRY; EXPERIMENTATION; PLATFORM; OPTIMIZATION; DESIGN;
D O I
10.1039/d3cc06180a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
High-throughput continuous flow technology has emerged as a revolutionary approach in chemical synthesis, offering accelerated experimentation and improved efficiency. With the aid of process analytical technology and automation, this system not only enables rapid optimisation of reaction conditions at the millimole to the picomole scale, but also facilitates automated scale-up synthesis. It can even achieve the self-planning and self-synthesis of small drug molecules with artificial intelligence incorporated in the system. The versatility of the system is highlighted by its compatibility with both electrochemistry and photochemistry, and its significant applications in organic synthesis and drug discovery. This highlight summarises its recent developments and applications, emphasising its significant impact on advancing research across multiple disciplines. High-throughput continuous flow technology has emerged as a revolutionary approach in chemical synthesis, offering accelerated experimentation and improved efficiency.
引用
收藏
页码:3217 / 3225
页数:9
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