High-throughput continuous flow technology has emerged as a revolutionary approach in chemical synthesis, offering accelerated experimentation and improved efficiency. With the aid of process analytical technology and automation, this system not only enables rapid optimisation of reaction conditions at the millimole to the picomole scale, but also facilitates automated scale-up synthesis. It can even achieve the self-planning and self-synthesis of small drug molecules with artificial intelligence incorporated in the system. The versatility of the system is highlighted by its compatibility with both electrochemistry and photochemistry, and its significant applications in organic synthesis and drug discovery. This highlight summarises its recent developments and applications, emphasising its significant impact on advancing research across multiple disciplines. High-throughput continuous flow technology has emerged as a revolutionary approach in chemical synthesis, offering accelerated experimentation and improved efficiency.
机构:
GlaxoSmithKline, Pharmaceut Res & Dev, Collegeville, PA 19426 USAVertex Pharmaceut Inc, Boston, MA 02210 USA
Bahr, Matthew N.
Morris, Mark A.
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Vertex Pharmaceut Inc, Boston, MA 02210 USAVertex Pharmaceut Inc, Boston, MA 02210 USA
Morris, Mark A.
Tu, Noah P.
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AbbVie Inc, N Chicago, IL 60064 USAVertex Pharmaceut Inc, Boston, MA 02210 USA
Tu, Noah P.
Nandkeolyar, Aakankschit
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GlaxoSmithKline, Pharmaceut Res & Dev, Collegeville, PA 19426 USA
Drexel Univ, Philadelphia, PA 19104 USAVertex Pharmaceut Inc, Boston, MA 02210 USA