Gut microbiota disparities between active Crohn's disease and healthy controls: A global systematic review

Purpose: Crohn's disease (CD) is challenging to manage. It has been suggested that modifying the gut microbiota could be a treatment strategy. We performed this systematic review to compare the gut microbiota between active CD and healthy controls. Results: The family Enterobacteriaceae and genus Bacteroides were increased in active CD compared to controls in 13 and 8 studies, respectively. The family Oscillospiraceae and genus Faecalibacterium decreased in active CD vs controls in 12 and 10 studies, respectively. Conclusion: Specific bacteria were associated with the microbiomes of active CD patients versus controls, offering insights into potential microbial targets for CD treatments.