Adolescence is not homogeneous; differences and needs are shaped by gender, ethnicity, or particular abilities. This study addressed the research problem: What teaching strategies allow for addressing comprehensive sexuality education content, considering the diversity of adolescents present in the classroom? The objective was to identify strategies in comprehensive sexuality education for adolescents, considering their social inclusion by gender, interculturality and functionality. The methodology started from the interpretive paradigm with a qualitative approach; as a method the systemic review and case study; and the techniques used, documentary review and semi-structured interview. It concludes that inclusive strategies, seen as pedagogical innovations, like sexuality as a human right within the framework of education for all, their purpose is responsible decision-making. Different problems and needs are evident in sexuality education between men and women that question the inputs of "majority" and "normality".