The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

被引：21

作者：

Limoli, Charles L. ^{[1
]}

Kramar, Eniko A. ^{[2
]}

Almeida, Aymeric ^{[3
,4
]}

Petit, Benoit ^{[3
,4
]}

Grilj, Veljko ^{[3
,4
]}

Baulch, Janet E. ^{[1
]}

Ballesteros-Zebadua, Paola ^{[3
,4
,5
]}

Loo, Billy W., Jr. ^{[6
]}

Wood, Marcelo A. ^{[2
]}

Vozenin, Marie -Catherine ^{[3
,4
,7
]}

机构：

[1] Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

[3] Lausanne Univ Hosp, Dept Radiat Oncol, Lab Radiat Oncol, Lausanne, Switzerland

[4] Univ Lausanne, Lausanne, Switzerland

[5] Inst Nacl Neurol & Neurocirugia MVS, Lab Fis Med, Mexico City 14269, Mexico

[6] Stanford Univ, Dept Radiat Oncol, Sch Med, Stanford, CA 94305 USA

[7] Univ Vaudois, Lab Radiooncol, Ctr Hosp, Bugnon 46, CH-1011 Lausanne, Switzerland

来源：

RADIOTHERAPY AND ONCOLOGY | 2023年 / 186卷

基金：

瑞士国家科学基金会;

关键词：

FLASH radiotherapy; Long-term potentiation; Standard-of care fractionation; WHOLE-BRAIN RADIOTHERAPY; AVOIDANCE; MEMANTINE; MEMORY;

D O I：

10.1016/j.radonc.2023.109767

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.& COPY; 2023 The Authors. Published by Elsevier B.V. Radiotherapy and Oncology 186 (2023) 109767 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：4

共 13 条

[11] Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice
Beregovoy, N. A.
Volcho, G. K.
Starostina, M. V.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2025, 178 (03) : 291 - 294
[12] A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints
Drayson, Olivia G. G.
Melemenidis, Stavros
Katila, Nikita
Viswanathan, Vignesh
Zhang, Richard
Kim, Rachel
Ru, Ning
Petit, Benoit
Dutt, Suparna
Manjappa, Rakesh
Ashraf, M. Ramish
Lau, Brianna
Soto, Luis
Skinner, Lawrie
Yu, Amu S.
Surucu, Murat
Maxim, Peter G.
Zebadua-Ballasteros, Paola
Wood, Marcelo A.
Montay-Gruel, Pierre
Baulch, Janet E.
Vozenin, Marie-Catherine
Loo Jr, Billy W.
Limoli, Charles L.
RADIOTHERAPY AND ONCOLOGY, 2024, 201
[13] Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice
McNamara, RK
Hussain, RJ
Simon, EJ
Stumpo, DJ
Blackshear, PJ
Abel, T
Lenox, RH
HIPPOCAMPUS, 2005, 15 (05) : 675 - 683

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