The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

被引：21

作者：

Limoli, Charles L. ^{[1
]}

Kramar, Eniko A. ^{[2
]}

Almeida, Aymeric ^{[3
,4
]}

Petit, Benoit ^{[3
,4
]}

Grilj, Veljko ^{[3
,4
]}

Baulch, Janet E. ^{[1
]}

Ballesteros-Zebadua, Paola ^{[3
,4
,5
]}

Loo, Billy W., Jr. ^{[6
]}

Wood, Marcelo A. ^{[2
]}

Vozenin, Marie -Catherine ^{[3
,4
,7
]}

机构：

[1] Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

[3] Lausanne Univ Hosp, Dept Radiat Oncol, Lab Radiat Oncol, Lausanne, Switzerland

[4] Univ Lausanne, Lausanne, Switzerland

[5] Inst Nacl Neurol & Neurocirugia MVS, Lab Fis Med, Mexico City 14269, Mexico

[6] Stanford Univ, Dept Radiat Oncol, Sch Med, Stanford, CA 94305 USA

[7] Univ Vaudois, Lab Radiooncol, Ctr Hosp, Bugnon 46, CH-1011 Lausanne, Switzerland

来源：

RADIOTHERAPY AND ONCOLOGY | 2023年 / 186卷

基金：

瑞士国家科学基金会;

关键词：

FLASH radiotherapy; Long-term potentiation; Standard-of care fractionation; WHOLE-BRAIN RADIOTHERAPY; AVOIDANCE; MEMANTINE; MEMORY;

D O I：

10.1016/j.radonc.2023.109767

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.& COPY; 2023 The Authors. Published by Elsevier B.V. Radiotherapy and Oncology 186 (2023) 109767 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：4

共 13 条

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PHYSICS IN MEDICINE AND BIOLOGY, 2024, 69 (19):
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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2024, 120 (02): : E202 - E203
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Jin, J. Y.
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