Green and Efficient One-Pot Synthesis of 9-(1H-Indol-2-yl)-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones

The indole-conjugated tetrazolo and quinazoline scaffolds play a pivotal role in the composition of various novel chemical compounds renowned for their medicinal activity. The synthesis involved the treatment of 1H-indole-2-carbaldehyde, 1H-tetrazol-5-amine, and cyclohexane-1,3-diones with [BMIM][OH] serving as a green reaction medium at 70-75(degrees)C for 40-60 min. This process yielded 9-(1H-indol-2-yl)-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones with an impressive 80-85% yield, and the structural elucidation was accomplished through NMR and Mass spectrometry analyses. Noteworthy advantages of this synthetic approach include its high yields, straightforward protocol, environmental friendliness, concise reaction times, and mild reaction conditions. The utilization of a catalytically active ionic liquid as the reaction medium eliminates the necessity for an additional catalyst and solvent, enhancing the efficiency and sustainability of the overall synthetic procedure.