Electrochemical Analysis of Antipsychotic Drug Quetiapine Fumarate Using Multi-walled Carbon Nanotube Modified Glassy Carbon Electrode

Electrochemical properties of quetiapine fumarate were examined on the anodic direction with multi-walled carbon nanotube modified glassy carbon electrode using voltammetric methods. The ratio of multi-walled carbon nanotube has been optimized using its various concentrations. The oxidation process was found to be irreversible, and adsorption controlled. The linear ranges were determined as 4x10(-9)-2x10(-6) M for differential pulse stripping voltammetry and 2x10(-9)-2x10(-6) M for square-wave stripping voltammetry with detection limits of 8.07x10(-10) and 2.71x10(-10) M, respectively. The methods were validated and successfully applied for the analysis of quetiapine fumarate tablets. The groups responsible for the oxidation reaction of quetiapine fumarate were investigated with model substances.