The Roles of hnRNP Family in the Brain and Brain-Related Disorders

被引：6
|
作者：
Brandao-Teles, Caroline [1 ]
Antunes, Andre S. L. M. [2 ]
Vrechi, Talita Aparecida de Moraes [1 ]
Martins-de-Souza, Daniel [1 ,3 ,4 ,5 ,6 ]
机构：
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, Campinas, Brazil
[2] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Campinas, Brazil
[3] Or Inst Res & Educ IDOR, Sao Paulo, Brazil
[4] Univ Estadual Campinas, Expt Med Res Cluster EMRC, BR-13083862 Campinas, SP, Brazil
[5] INCT Modelling Human Complex Dis 3D Platforms Mode, Sao Paulo, Brazil
[6] Inst Nacl Biomarcadores Neuropsiquiatria, Conselho Nacl Desenvolvimento Cientif & Tecnol, Sao Paulo, Brazil
来源：
MOLECULAR NEUROBIOLOGY | 2024年 / 61卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
hnRNP; Schizophrenia; Central nervous system; Neurons; Oligodendrocytes; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS; FRONTOTEMPORAL LOBAR DEGENERATION; MBP MESSENGER-RNA; GENOME-WIDE DETECTION; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; SYNAPTIC PLASTICITY; PROTEOMIC ANALYSIS; PREFRONTAL CORTEX; APP TRANSLATION;
D O I：
10.1007/s12035-023-03747-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to a complex family of RNA-binding proteins that are essential to control alternative splicing, mRNA trafficking, synaptic plasticity, stress granule formation, cell cycle regulation, and axonal transport. Over the past decade, hnRNPs have been associated with different brain disorders such as Alzheimer's disease, multiple sclerosis, and schizophrenia. Given their essential role in maintaining cell function and integrity, it is not surprising that dysregulated hnRNP levels lead to neurological implications. This review aims to explore the primary functions of hnRNPs in neurons, oligodendrocytes, microglia, and astrocytes, and their roles in brain disorders. We also discuss proteomics and other technologies and their potential for studying and evaluating hnRNPs in brain disorders, including the discovery of new therapeutic targets and possible pharmacological interventions.
引用
收藏
页码：3578 / 3595
页数：18
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