Affinity selection mass spectrometry speeding drug discovery

被引：10

作者：

Prudent, Renaud ^{[1
]}

Lemoine, Hugues ^{[1
]}

Walsh, Jarrod ^{[2
]}

Roche, Didier ^{[1
]}

机构：

[1] Edelris, Bioparc,Bioserra 1 Bldg, Lyon, France

[2] AstraZeneca, R&D BioPharmaceut, Discovery Sci, High Throughput Screening,Hit Discovery, Alderley Pk, England

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 11期

关键词：

af finity selection mass spectrometry; hit identi fication; drug discovery; COMBINATORIAL LIBRARIES; HIT IDENTIFICATION; LIGANDS; CHROMATOGRAPHY; TECHNOLOGIES; INHIBITORS; EVOLUTION; MAGMASS; SITE; MS;

D O I：

10.1016/j.drudis.2023.103760

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Affinity selection mass spectrometry (AS-MS) has gained momentum in drug discovery. This review summarizes how this technology has slowly risen as a new paradigm in hit identification and its potential synergy with DNA encoded library technology. It presents an overview of the recent results on challenging targets and perspectives on new areas of research, such as RNA targeting with small molecules. The versatility of the approach is illustrated and strategic drivers discussed in terms of the experience of a small-medium CRO and a big pharma organization.

引用

页数：8

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