A high-precision automated liquid pipetting device with an interchangeable tip

被引：2
|
作者：
Yang, Xin [1 ,2 ]
Wang, Xiaojie [1 ,2 ]
Li, Baoqing [1 ,2 ]
Chu, Jiaru [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Dept Precis Machinery & Precis Instrumentat, Hefei 230027, Anhui, Peoples R China
[2] Univ Sci & Technol China, Key Lab Precis Sci Instrumentat Anhui Higher Educ, Hefei 230027, Anhui, Peoples R China
来源：
REVIEW OF SCIENTIFIC INSTRUMENTS | 2023年 / 94卷 / 09期
关键词：
IMPACT; DISPENSER; PRINTER;
D O I：
10.1063/5.0139565
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Liquid handling is a necessary act to deal with liquid samples from scientific labs to industry. However, existing pipetting devices suffer from inaccuracy and low precision when dealing with submicroliter liquids, which significantly affect their applications in low-volume quantitation. In this article, we present an automated liquid pipetting device that can aspirate liquid from microplates and dispense nanoliter droplets with high precision. Liquid aspiration is realized by using a micropump and a solenoid valve, and on-demand nanoliter droplet printing is realized by using a low-cost and interchangeable pipette tip combined with a piezoelectric actuator. Based on the microfluidic printing technology, the volumetric coefficient of variation of the dispensed liquid is less than 2% below 1 mu l. A demonstration of concentration dilution for quantitative analysis has been successfully performed using the automated liquid pipetting device, demonstrating its potential in low-volume liquid handling for a wide range of biomedical applications. Published under an exclusive license by AIP Publishing. https://doi.org/10.1063/5.0139565
引用
收藏
页数：13
相关论文
共 50 条
  • [31] High-precision Time-to-Digital Converters in a FPGA device
    Aloisio, A.
    Branchini, P.
    Cicalese, R.
    Giordano, R.
    Izzo, V.
    Loffredo, S.
    2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9, 2009, : 1389 - +
  • [32] Development of high-precision calibration instrument for MOA measurement device
    Wang, Ya-Jun
    Shu, Nai-Qiu
    Zeng, Xi-Wen
    Wei, Xing
    Dianli Zidonghua Shebei / Electric Power Automation Equipment, 2005, 25 (11): : 84 - 85
  • [33] High-precision Time-to-Digital Converter in a FPGA device
    Aloisio, A.
    Branchini, P.
    Giordano, R.
    Izzo, V.
    Loffredo, S.
    2009 16TH IEEE-NPSS REAL TIME CONFERENCE, 2009, : 283 - +
  • [34] AN IMPROVED HIGH-PRECISION DEVICE FOR ASTROMETRIC OBSERVATIONS IN LUNAR CONDITIONS
    GURSHTEIN, AA
    ASTRONOMICHESKII ZHURNAL, 1985, 62 (06): : 1218 - 1226
  • [35] HIGH-PRECISION MAGNETIC-LEVITATION DEVICE WITH ELECTROOPTICAL FEEDBACK
    ECHEVERRIA, I
    RUBIO, MA
    REVIEW OF SCIENTIFIC INSTRUMENTS, 1995, 66 (07): : 3931 - 3938
  • [36] High-precision Time-to-Digital Converter in a FPGA device
    Aloisio, A.
    Branchini, P.
    Giordano, R.
    Izzo, V.
    Loffredo, S.
    2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5, 2009, : 290 - +
  • [37] MEASURING THE VERDET CONSTANT - A SIMPLE, HIGH-PRECISION, AUTOMATIC DEVICE
    BREVETPHILIBERT, O
    BRUNETTON, R
    MONIN, J
    JOURNAL OF PHYSICS E-SCIENTIFIC INSTRUMENTS, 1988, 21 (07): : 647 - 649
  • [38] High-precision automated reconstruction of neurons with flood-filling networks
    Michał Januszewski
    Jörgen Kornfeld
    Peter H. Li
    Art Pope
    Tim Blakely
    Larry Lindsey
    Jeremy Maitin-Shepard
    Mike Tyka
    Winfried Denk
    Viren Jain
    Nature Methods, 2018, 15 : 605 - 610
  • [39] Techniques for automated high-precision photometry of Sun-like stars
    Henry, GW
    PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF THE PACIFIC, 1999, 111 (761) : 845 - 860
  • [40] MODIFIED WHEATSTONE BRIDGE FOR HIGH-PRECISION AUTOMATED RESISTANCE MEASUREMENT.
    Sasaki, Hitoshi
    Nishinaka, Hidefumi
    Shida, Katsunori
    1947, (26):
12345