Survival outcomes in phase I trial combining VCN-01 and durvalumab (MEDI4736) in subjects with recurrent/ metastatic head and neck squamous cell carcinoma refractory to previous immunotherapy treatment

被引:0
|
作者
Jove, M. [1 ]
Brana, I. [2 ,3 ]
Oliva Bernal, M. [4 ]
Hernando Calvo, A.
Erasun Lecuona, C. [4 ]
Assaf Pastrana, J. D. [2 ,3 ]
Mato-Berciano, A. [5 ]
V. Maliandi, M. [5 ]
Torres-Manjon, S. [6 ]
Moreno, R. [6 ]
Le, C. [7 ]
G. Nuciforo, P. [8 ]
Alemany, R. [6 ]
Capella, G. [9 ]
Blasco, C. [10 ]
Cascallo Piqueras, M. [10 ]
Mesia Nin, R. [11 ]
机构
[1] Catalan Inst Oncol ICO, Med Oncol Phase Funct Unit 1, Lhospitalet De Llobregat, Spain
[2] Vall dHebron Hosp Univ, Med Oncol Dept, Barcelona, Spain
[3] Vall dHebron Inst Oncol VHIO, Barcelona, Spain
[4] Catalan Inst Oncol ICO, Med Oncol Phase Funct Unit 1, Barcelona, Spain
[5] Theriva Biol, R&D, Parets Del Valles, Spain
[6] ICO Inst Catala Oncol Hosp Duran I Reynals, IDIBELL, ProCure Program ICO Program Mol Mech & Expt Ther, Lhospitalet De Llobregat, Spain
[7] Theriva Biol, Stat & Analyt, Rockville, MD USA
[8] Vall dHebron Inst Oncol VHIO Cellex Ctr, Mol Oncol Dept, Barcelona, Spain
[9] IDIBELL, Program Mol Mech & Expt Therapy Oncol Oncobell, Lhospitalet De Llobregat, Spain
[10] Theriva Biol, Clin Operat, Parets Del Valles, Spain
[11] IGTP, ICO Inst Catala Oncol, Med Oncol Dept, B ARGO Grp, Badalona, Spain
关键词
D O I
10.1016/j.annonc.2023.09.2081
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
937P
引用
收藏
页码:S589 / S590
页数:2
相关论文
共 50 条
  • [41] A multi-center phase II trial evaluating the efficacy of palbociclib in combination with carboplatin for the treatment of unresectable recurrent or metastatic head and neck squamous cell carcinoma
    Paul L. Swiecicki
    Greg Durm
    Emily Bellile
    Apurva Bhangale
    J. Chad Brenner
    Francis P. Worden
    Investigational New Drugs, 2020, 38 : 1550 - 1558
  • [42] A multi-center phase II trial evaluating the efficacy of palbociclib in combination with carboplatin for the treatment of unresectable recurrent or metastatic head and neck squamous cell carcinoma
    Swiecicki, Paul L.
    Durm, Greg
    Bellile, Emily
    Bhangale, Apurva
    Brenner, J. Chad
    Worden, Francis P.
    INVESTIGATIONAL NEW DRUGS, 2020, 38 (05) : 1550 - 1558
  • [43] Phase II trial of combination treatment with S-1/cetuximab in patients with platinum-ineligible recurrent and/or metastatic squamous cell carcinoma of the head and neck
    Jun Taguchi
    Yasushi Shimizu
    Shin Ariga
    Tomohiro Goda
    Yoshihito Ohhara
    Rio Honma
    Takuro Noguchi
    Satoshi Takeuchi
    Ichiro Kinoshita
    Toraji Amano
    Takatsugu Mizumachi
    Satoshi Kano
    Miki Takahara
    Takahisa Abe
    Akihiro Homma
    Hirotoshi Dosaka-Akita
    International Journal of Clinical Oncology, 2021, 26 : 51 - 58
  • [44] Cabazitaxel in patients with refractory recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): Final results of phase II trial UNICANCER ORL03
    Fayette, J.
    Guigay, J.
    Letourneau, C.
    Degardin, M.
    Peyrade, F.
    Orlandini, F.
    Buffard, K.
    Bellera, C.
    EUROPEAN JOURNAL OF CANCER, 2015, 51 : S557 - S557
  • [45] Phase I trial of palbociclib, a selective cyclin dependent kinase 4/6 inhibitor, in combination with cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma
    Michel, Loren
    Ley, Jessica
    Wildes, Tanya M.
    Schaffer, Andras
    Robinson, Anthony
    Chun, Se-Eun
    Lee, Wooin
    Lewis, James, Jr.
    Trinkaus, Kathryn
    Adkins, Douglas
    ORAL ONCOLOGY, 2016, 58 : 41 - 48
  • [46] Lenvatinib with or without pembrolizumab versus chemotherapy for treatment of recurrent or metastatic head and neck squamous cell carcinoma that progressed on platinum therapy and immunotherapy: Phase 2 LEAP-009
    Harrington, Kevin J.
    Kim, Hye Ryun
    Salas, Sebastien
    Oliva, Marc
    Metcalf, Robert
    Bernsdorf, Mogens
    Kim, Ji-Won
    Cohen, Ezra E. W.
    Siu, Lillian
    Rischin, Danny
    Licitra, Lisa
    Vermorken, Jan
    Quynh Le
    Tahara, Makoto
    Machiels, Jean-Pascal
    O'Hara, Karen
    Pathiraja, Kumudu
    Gumuscu, Burak
    Bidadi, Behzad
    Burtness, Barbara
    CLINICAL CANCER RESEARCH, 2023, 29 (18)
  • [47] Outcomes of Phase I Trial of Patients With Recurrent Head and Neck Squamous Cell Carcinoma Treated With Re-Irradiation With Stereotactic Body Radiation Therapy and Concurrent Cisplatin
    Echevarria, M.
    Chung, C.
    Kirtane, K.
    Kish, J. A.
    Muzaffar, J.
    Caudell, J. J.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2021, 111 (03): : E369 - E369
  • [48] Concurrent Cetuximab and Nivolumab as a Second-Line or beyond Treatment of Patients with Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results of Phase I/II Study
    Chung, Christine H.
    Bonomi, Marcelo
    Steuer, Conor E.
    Li, Jiannong
    Bhateja, Priyanka
    Johnson, Matthew
    Masannat, Jude
    Song, Feifei
    Hernandez-Prera, Juan C.
    Wenig, Bruce M.
    Molina, Helen
    Farinhas, Joaquim M.
    McMullen, Caitlin P.
    Wadsworth, J. Trad
    Patel, Krupal B.
    Kish, Julie A.
    Muzaffar, Jameel
    Kirtane, Kedar
    Rocco, James W.
    Schell, Michael J.
    Saba, Nabil F.
    CANCERS, 2021, 13 (05) : 1 - 16
  • [49] A phase I study to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary clinical activity of MEDI0562 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN).
    Leidner, Rom Samuel
    Patel, Sandip Pravin
    Fury, Matthew G.
    Ferris, Robert L.
    McDevitt, Jennifer T.
    Lanasa, Mark C.
    Glisson, Bonnie S.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [50] A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial
    Galot, Rachel
    Le Tourneau, Christophe
    Saada-Bouzid, Esma
    Daste, Amaury
    Even, Caroline
    Debruyne, Philip
    Henry, Stephanie
    Zanetta, Sylvie
    Rutten, Anemie
    Licitra, Lisa
    Canon, Jean-Luc
    Kaminsky, Marie-Christine
    Specenier, Pol
    Rottey, Sylvie
    Guigay, Joel
    Kong, Anthony
    Tinhofer, Inge
    Borcoman, Edith
    Dirix, Lieve
    Raveloarivahy, Tiana
    Fortpied, Catherine
    Vanlancker, Maureen
    Morfouace, Marie
    Govaerts, Anne-Sophie
    Machiels, Jean-Pascal
    EUROPEAN JOURNAL OF CANCER, 2021, 158 : 17 - 26