Synthesis, Crystal Structures and Antibacterial Activity of Nickel(II) and Copper(II) Complexes Derived from (E)-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)-N-phenylhydrazinecarbothioamide

被引：0

作者：

Wang, Jing ^{[1
]}

Fei, Haiyang ^{[1
]}

Zhou, Min ^{[1
]}

Zhang, Chengcai ^{[1
]}

Sun, Juan ^{[2
]}

Zhou, Yang ^{[3
]}

Yang, Meng ^{[1
]}

机构：

[1] Jiangsu Food & Pharmaceut Sci Coll, Sch Pharmaceut Engn, Huaian 223005, Peoples R China

[2] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310023, Peoples R China

[3] Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315300, Peoples R China

来源：

ACTA CHIMICA SLOVENICA | 2024年 / 71卷 / 01期

关键词：

1; 4-Benzodioxane; nickel complex; copper complex; antibacterial activity; FabH inhibitory; ANTIMICROBIAL ACTIVITY; DESIGN;

D O I：

10.17344/acsi.2023.8397

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biosynthesis of fatty acids is essential for the survival of bacteria, and beta-ketoacyl-acyl carrier protein synthase III (FabH) is a promising target for antibacterial drug development. Nickel(II) complex [NiL2] (1) and copper(II) complex [CuL2] (2), where L is (E)-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)-N-phenylhydrazinecarbothioamide, were synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy and HRMS. Structures of the complexes were further studied by single crystal X-ray determination, which reveals that the nickel and copper atoms in the complexes are in tetrahedral geometry. These compounds were evaluated for their antibacterial and E. coli FabH inhibitory activities.

引用

页码：20 / 25

页数：6

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