Synthesis, Crystal Structures and Antibacterial Activity of Nickel(II) and Copper(II) Complexes Derived from (E)-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)-N-phenylhydrazinecarbothioamide

被引：0
|
作者：
Wang, Jing [1 ]
Fei, Haiyang [1 ]
Zhou, Min [1 ]
Zhang, Chengcai [1 ]
Sun, Juan [2 ]
Zhou, Yang [3 ]
Yang, Meng [1 ]
机构：
[1] Jiangsu Food & Pharmaceut Sci Coll, Sch Pharmaceut Engn, Huaian 223005, Peoples R China
[2] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310023, Peoples R China
[3] Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315300, Peoples R China
来源：
ACTA CHIMICA SLOVENICA | 2024年 / 71卷 / 01期
关键词：
1; 4-Benzodioxane; nickel complex; copper complex; antibacterial activity; FabH inhibitory; ANTIMICROBIAL ACTIVITY; DESIGN;
D O I：
10.17344/acsi.2023.8397
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The biosynthesis of fatty acids is essential for the survival of bacteria, and beta-ketoacyl-acyl carrier protein synthase III (FabH) is a promising target for antibacterial drug development. Nickel(II) complex [NiL2] (1) and copper(II) complex [CuL2] (2), where L is (E)-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)-N-phenylhydrazinecarbothioamide, were synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy and HRMS. Structures of the complexes were further studied by single crystal X-ray determination, which reveals that the nickel and copper atoms in the complexes are in tetrahedral geometry. These compounds were evaluated for their antibacterial and E. coli FabH inhibitory activities.
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收藏
页码：20 / 25
页数：6
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