Palladium-catalyzed radical arylation of N-hydroxyphthalimides with triphenyl phosphites as an unusual arylating agent via C(sp2)-O bond cleavage

被引：2

作者：

Noor, Hafiz ^{[1
,2
]}

Gao, Pan ^{[1
]}

Guo, Jiandong ^{[1
]}

Zhang, Shuwei ^{[1
]}

Jia, Xiaodong ^{[1
]}

Yuan, Yu ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu Provinc, Peoples R China

[2] Univ Al Fashir, Fac Educ, Dept Chem, Al Fashir, Sudan

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 04期

基金：

中国国家自然科学基金;

关键词：

BENZYL BROMIDE; ARYL RADICALS; GENERATION; ETHERS; ARYLHYDRAZINES; ADDUCTS; ARENES; ESTERS;

D O I：

10.1039/d3qo01919e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a new strategy for the palladium-catalyzed radical arylation of N-hydroxyphthalimides with triphenyl phosphites via C(sp(2))-O bond cleavage. In this protocol, N-hydroxyphthalimides have been arylated with triphenyl phosphites to provide N-aryloxyimides with a wide range of functional group tolerance. In addition, electron paramagnetic resonance (EPR) was conducted, which revealed the presence of the phenyl radical in the reaction system. Further control experiments were also performed, which strongly supported a radical cross-coupling pathway.

引用

页码：1069 / 1075

页数：7

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