Crosstalk of nervous and immune systems in pancreatic cancer

被引：1
|
作者：
Huang, Fei-Fei [1 ]
Cui, Wen-Hui [1 ]
Ma, Lan-Yue [2 ,3 ,4 ]
Chen, Qi [2 ,3 ]
Liu, Yang [1 ]
机构：
[1] South China Univ Technol, Sch Med, Innovat Ctr, Minist Educ Dev & Dis, Guangzhou, Peoples R China
[2] Chinese Acad Sci, Guangdong Prov Key Lab Stem Cell & Regenerat Med, GIBH CUHK Joint Res Lab Stem Cell & Regenerat Med,, Ctr Cell Lineage & Dev,Guangzhou Inst Biomed & Hlt, Guangzhou, Peoples R China
[3] China New Zealand Joint Lab Biomed & Hlth, Guangzhou, Peoples R China
[4] Univ Chinese Acad Sci, Beijing, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
pancreatic cancer; peripheral nerve; immune cells; neural-immune crosstalk; PDAC (pancreatic ductal adenocarcinoma); VASOACTIVE-INTESTINAL-PEPTIDE; PROMOTES PERINEURAL INVASION; NEUROGENIC INFLAMMATION; DUCTAL ADENOCARCINOMA; MACROPHAGE INFILTRATION; TUMOR MICROENVIRONMENT; MOLECULAR-MECHANISMS; SYMPATHETIC-NERVE; SENSORY NEURONS; SUBSTANCE-P;
D O I：
10.3389/fcell.2023.1309738
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pancreatic cancer is a highly malignant tumor known for its extremely low survival rate. The combination of genetic disorders within pancreatic cells and the tumor microenvironment contributes to the emergence and progression of this devastating disease. Extensive research has shed light on the nature of the microenvironmental cells surrounding the pancreatic cancer, including peripheral nerves and immune cells. Peripheral nerves release neuropeptides that directly target pancreatic cancer cells in a paracrine manner, while immune cells play a crucial role in eliminating cancer cells that have not evaded the immune response. Recent studies have revealed the intricate interplay between the nervous and immune systems in homeostatic condition as well as in cancer development. In this review, we aim to summarize the function of nerves in pancreatic cancer, emphasizing the significance to investigate the neural-immune crosstalk during the advancement of this malignant cancer.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] Modulating the cross-talk between the immune and nervous systems to treat rectal cancer
    Uccello, Taylor Paige
    Mills, Bradley N.
    Repasky, Elizabeth A.
    Lord, Edith M.
    Linehan, David C.
    Gerber, Scott A.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [42] Crosstalk between cancer-associated fibroblasts and immune cells in cancer
    An, Yuanyuan
    Liu, Fengtian
    Chen, Ying
    Yang, Qing
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (01) : 13 - 24
  • [43] Interactions between the immune and nervous systems in pain
    Ke Ren
    Ronald Dubner
    Nature Medicine, 2010, 16 : 1267 - 1276
  • [44] Interaction between the immune and central nervous systems
    Russell, JH
    IMMUNOLOGIC RESEARCH, 2005, 32 (1-3) : 225 - 229
  • [45] Interaction between the immune and central nervous systems
    John H. Russell
    Immunologic Research, 2005, 32 : 225 - 229
  • [46] The nervous and the immune systems: conspicuous physiological analogies
    Julio Sotelo
    Journal of Comparative Physiology A, 2015, 201 : 185 - 194
  • [47] Interactions between the immune and nervous systems in pain
    Ren, Ke
    Dubner, Ronald
    NATURE MEDICINE, 2010, 16 (11) : 1267 - 1276
  • [48] Interactions between Nervous and Immune Systems in Rheumatology
    Baerwald, Christoph
    AKTUELLE RHEUMATOLOGIE, 2013, 38 (04) : 217 - 217
  • [49] RanBPM, a scaffolding protein in the immune and nervous systems
    Murrin, L. Charles
    Talbot, Jeffery N.
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2007, 2 (03) : 290 - 295
  • [50] INTERACTIONS BETWEEN THE NERVOUS AND THE IMMUNE-SYSTEMS
    GILBERT, MS
    PAYAN, DG
    FRONTIERS IN NEUROENDOCRINOLOGY, 1991, 12 (04) : 299 - 322
12345