hepatoid adenocarcinoma of the lung;
alpha-fetoprotein;
anti-PD-1;
therapy;
brain metastases;
case report;
D O I:
10.3389/fonc.2023.1257931
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Hepatoid adenocarcinoma of the lung (HAL) is extremely rare; a standardized treatment strategy for HAL has not been established. The prognosis of patients with unresectable HAL is extremely poor. Here, we reported a 64-year-old male patient with unresectable alpha-fetoprotein-producing HAL who showed moderate harboring programmed death ligand 1 (PD-L1) expression and no targetable driver mutations. The patient was treated with brain radiotherapy, multiple lines of chemotherapies, and PD-1 inhibitor and achieved a survival rate of 9 months. The patient finally died because of the progression of brain metastasis. The case report provides valuable information for the treatment strategy development of advanced HAL patients and reminds us of the therapeutic particularity of brain metastasis.
机构:
Wuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
Wu, Na
Yang, Xiaoxin
论文数: 0引用数: 0
h-index: 0
机构:
Anhui Med Univ, Navy Clin Coll, Sch Clin Med 5, Hefei, Anhui, Peoples R ChinaWuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
Yang, Xiaoxin
Zhai, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
Zhai, Yan
Lu, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Intervent Diagnost & Therapeut Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
机构:
Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
China Japan Friendship Hosp, Dept Pediat, Beijing, Peoples R ChinaBeijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
Liu, Shufang
Niu, Wenquan
论文数: 0引用数: 0
h-index: 0
机构:
China Japan Friendship Hosp, Inst Clin Med Sci, 2 Yinghua East St, Beijing 100029, Peoples R ChinaBeijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Chen, Gang
Huang, Alexander C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Huang, Alexander C.
Zhang, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Zhang, Wei
Zhang, Gao
论文数: 0引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, 3601 Spruce St, Philadelphia, PA 19104 USA
Wistar Inst Anat & Biol, Melanoma Res Ctr, 3601 Spruce St, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Zhang, Gao
Wu, Min
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wu, Min
Xu, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Xu, Wei
Yu, Zili
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Yu, Zili
Yang, Jiegang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Yang, Jiegang
Wang, Beike
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wang, Beike
Sun, Honghong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Sun, Honghong
Xia, Houfu
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Xia, Houfu
Man, Qiwen
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Man, Qiwen
Zhong, Wenqun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Zhong, Wenqun
Antelo, Leonardo F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Antelo, Leonardo F.
Wu, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wu, Bin
Xiong, Xuepeng
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Xiong, Xuepeng
Liu, Xiaoming
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Liu, Xiaoming
Guan, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Xi An Jiao Tong Univ, Sch Life Sci, Key Lab Biomed Informat Engn, Minist Educ, Xian, Shaanxi, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Guan, Lei
Li, Ting
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Xi An Jiao Tong Univ, Sch Life Sci, Key Lab Biomed Informat Engn, Minist Educ, Xian, Shaanxi, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Li, Ting
Liu, Shujing
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Liu, Shujing
Yang, Ruifeng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Yang, Ruifeng
Lu, Youtao
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Lu, Youtao
Dong, Liyun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Dong, Liyun
McGettigan, Suzanne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
McGettigan, Suzanne
论文数: 引用数:
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机构:
Somasundaram, Rajasekharan
Radhakrishnan, Ravi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Sch Engn, Dept Bioengn, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Radhakrishnan, Ravi
Mills, Gordon
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Mills, Gordon
Lu, Yiling
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Lu, Yiling
Kim, Junhyong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Kim, Junhyong
Chen, Youhai H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Chen, Youhai H.
Dong, Haidong
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Dept Immunol, Rochester, MN USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Dong, Haidong
Zhao, Yifang
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan, Hubei, Peoples R ChinaUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Zhao, Yifang
Karakousis, Giorgos C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Karakousis, Giorgos C.
Mitchell, Tara C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Mitchell, Tara C.
Schuchter, Lynn M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Schuchter, Lynn M.
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机构:
Herlyn, Meenhard
Wherry, E. John
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Wherry, E. John
Xu, Xiaowei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA
Xu, Xiaowei
Guo, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USAUniv Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA