Hypervalent iodine(iii) promoted C-H/C-H amination/annulation tandem reactions: synthesis of benzimidazoles from simple anilines and aldehydes

被引：6

作者：

Long, Lipeng ^{[1
]}

Li, Xin ^{[1
]}

Tu, Mengshi ^{[1
]}

Zhang, Yekun ^{[1
]}

Qiao, Liang ^{[1
]}

Luo, Wenjun ^{[1
]}

Chen, Zhengwang ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Organo Pharmaceut Chem Jiangxi Prov, Ganzhou 341000, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 02期

关键词：

CATALYZED REGIOSPECIFIC SYNTHESIS; ONE-POT SYNTHESIS; OXIDATIVE ANNULATION; BOND FORMATION; DERIVATIVES; ROUTE; FUNCTIONALIZATION; CYCLIZATION; CHEMISTRY; ARYLATION;

D O I：

10.1039/d2qo01644c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel hypervalent iodine mediated cascade transformation of anilines and aldehydes to benzimidazoles was developed. A series of 1,2-disubstituted benzimidazoles were achieved with aromatic, heteroaromatic, and aliphatic aldehydes. In this procedure, the initial condensation of anilines with aldehydes afforded N-arylimine intermediates which underwent C-H/C-H amination/annulation to generate the desired products in moderate to excellent yields. This reaction is an extremely simple reaction system with good functional group tolerance, and water is the only byproduct formed.

引用

页码：473 / 479

页数：7

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