Conserved HIV-1 V3 loop helix offers potential for broad neutralization

被引：0

作者：

Trkola, Alexandra ^{[1
]}

Glogl, Matthias ^{[1
]}

机构：

[1] Univ Zurich, Inst Med Virol, Zurich, Switzerland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 09期

关键词：

PROTEINS;

D O I：

10.1038/s41594-023-01063-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using designed ankyrin repeat proteins (DARPins) technology, we discovered an alpha-helical conformation of the third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein that renders the virus susceptible to broad neutralization at an intermediate entry stage after binding the CD4 receptor. Our results highlight the potential of post-attachment neutralization and enable exploitation of this helical region for inhibitor and vaccine design.

引用

页码：1256 / 1257

页数：2

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