Conserved HIV-1 V3 loop helix offers potential for broad neutralization

被引：0
|
作者：
Trkola, Alexandra [1 ]
Glogl, Matthias [1 ]
机构：
[1] Univ Zurich, Inst Med Virol, Zurich, Switzerland
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 09期
关键词：
PROTEINS;
D O I：
10.1038/s41594-023-01063-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using designed ankyrin repeat proteins (DARPins) technology, we discovered an alpha-helical conformation of the third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein that renders the virus susceptible to broad neutralization at an intermediate entry stage after binding the CD4 receptor. Our results highlight the potential of post-attachment neutralization and enable exploitation of this helical region for inhibitor and vaccine design.
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页码：1256 / 1257
页数：2
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