The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers

被引:4
|
作者
Jamalidoust, Marzieh [1 ]
Eilami, Owrang [2 ]
Ashkan, Zahra [3 ]
Ziyaeyan, Mazyar [1 ]
Aliabadi, Nasrin [1 ]
Habibi, Mohammad [4 ]
机构
[1] Shiraz Univ Med Sci, Namazi Hosp, Prof Alborzi Clin Microbiol Res Ctr, Dept Virol, Shiraz 7193711351, Iran
[2] Shiraz Univ Med Sci, Dept Family Med & Infect Dis, Shiraz, Iran
[3] Shahrekord Univ, Fac Basic Sci, Dept Biol, Shahrekord, Iran
[4] Shiraz Univ Med Sci, Stat & Informat Technol Management, Shiraz, Iran
关键词
Breakthrough infection; Healthcare worker; Natural infection; SARS-C0V-2; Vaccination;
D O I
10.1186/s12985-023-02156-2
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background/AimsThe aim of this study was to determine the rate of natural and breakthrough infection and related symptoms of Covid-19 amongst Iranian healthcare workers (HCWs) who were vaccinated by different non-mRNA-based vaccines at peak points.MethodsIn this cross-sectional study, the RT-PCR test was performed for a total of 10,581 HCWs suspicious of Covid-19 infection. For each HCW, the frequency of SARS-CoV-2 infection and the time of transmission based on vaccination administration time and schedule were examined during different waves of the pandemic. Based on these findings, the study patients were divided into three groups: natural, natural/breakthrough, and breakthrough.ResultsIn total, 53% of the HCWs were exposed to SARS-CoV-2 infection between 1 and 5 times within two years after the current pandemic, while 20.7% and 32.3% experienced natural and breakthrough SARS-CoV-2 infection, respectively. Only 6% of the breakthrough-infected HCWs had naturally contracted SARS-CoV-2 infection during the initial waves. The highest natural peaks of infection occurred during the interval administration of the first and second dose of the first vaccination series, while the single highest peak of breakthrough infection belonged to the Omicron wave. It occurred simultaneously with the administration of the third vaccination dose. On the other hand, the highest rate of reinfection was observed amongst people who had received the Sinopharm and Bharat vaccines full-doses.ConclusionThis study compared the clinical differences between the two peaks of Omicron and Delta. This study indicates the rates of natural and breakthrough SARS-CoV-2 infections according to vaccination schedules and different waves of the pandemic.
引用
收藏
页数:8
相关论文
共 36 条
  • [11] Symptoms, antibody levels and vaccination attitude after asymptomatic to moderate COVID-19 infection in 200 healthcare workers
    Harsch, Igor Alexander
    Ortloff, Andrea
    Reinhofer, Mike
    Epstude, Jorg
    GMS HYGIENE AND INFECTION CONTROL, 2021, 16
  • [12] Urban-rural divide in COVID-19 infection and vaccination rates in healthcare workers in British Columbia, Canada
    Yassi, Annalee
    Barker, Stephen
    Lockhart, Karen
    Taylor, Deanne
    Harris, Devin
    Hundal, Harsh
    Grant, Jennifer M.
    Okpan, Arnold Ikedicbi
    Pollock, Sue
    Sprague, Stacy
    Sing, Chad Kim
    CANADIAN JOURNAL OF RURAL MEDICINE, 2023, 28 (02) : 47 - 58
  • [13] Investigating the pre- and post-COVID-19 vaccination infection status of Iranian dental students: a cross-sectional study
    Owlia, Fatemeh
    Kargar, Mohammad-Javad
    Kazemipoor, Maryam
    EGYPTIAN JOURNAL OF BRONCHOLOGY, 2025, 19 (01)
  • [14] COVID-19 booster vaccination uptake and infection breakthrough amongst health care workers in Wales: A national prospective cohort study br
    Bedston, Stuart
    Lowthian, Emily
    Jarvis, Christopher, I
    Akbari, Ashley
    Beggs, Jillian
    Bradley, Declan
    de Lusignan, Simon
    Griffiths, Rowena
    Helbert, Laura
    Hobbs, Richard
    Kerr, Steven
    Lyons, Jane
    Midgley, William
    Owen, Rhiannon K.
    Quintj, Jennifer K.
    Tsang, Ruby
    Torabi, Fatemeh
    Sheikh, Aziz
    Lyons, Ronan A.
    VACCINE, 2023, 41 (07)
  • [15] TWO- YEAR FOLLOW- UP OF POST- TRAUMATIC STRESS DISORDER SYMPTOMS IN HEALTHCARE WORKERS AFTER THE COVID-19 PANDEMIC IN CHINA
    Chen, Hao
    Ma, Qing
    Du, Bo
    Huang, Yan
    Zhu, Shi-Guang
    INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH, 2023, 36 (03) : 324 - 332
  • [16] COVID-19 Vaccination and Asymptomatic Infection Effect of BNT162b2 mRNA Vaccine on the Incidence of COVID-19 and Duration of Sick Leave Among Healthcare Workers
    Prato, Simone
    Paladino, Maria Emilia
    Riva, Michele Augusto
    Belingheri, Michael
    JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2021, 63 (12) : E868 - E870
  • [17] Healthcare workers benefit from second dose of COVID-19 mRNA vaccine: Effects of partial and full vaccination on sick leave duration and symptoms
    Strum, Earl
    Casagrande, Yolee
    Newton, Kim
    Unger, Jennifer B.
    PUBLIC HEALTH IN PRACTICE, 2022, 3
  • [18] Coronavirus Disease 2019 (COVID-19) Breakthrough Infection and Post-Vaccination Neutralizing Antibodies Among Healthcare Workers in a Referral Hospital in Tokyo: A Case-Control Matching Study
    Yamamoto, Shohei
    Maeda, Kenji
    Matsuda, Kouki
    Tanaka, Akihito
    Horii, Kumi
    Okudera, Kaori
    Takeuchi, Junko S.
    Mizoue, Tetsuya
    Konishi, Maki
    Ozeki, Mitsuru
    Sugiyama, Haruhito
    Aoyanagi, Nobuyoshi
    Mitsuya, Hiroaki
    Sugiura, Wataru
    Ohmagari, Norio
    CLINICAL INFECTIOUS DISEASES, 2022, 75 (01) : E683 - E691
  • [19] Analysis of the Economic Burden of COVID-19 on the Workers of a Teaching Hospital in the Centre of Italy: Changes in Productivity Loss and Healthcare Costs Pre and Post Vaccination Campaign
    Di Fabio, Sara
    La Torre, Giuseppe
    VACCINES, 2023, 11 (12)
  • [20] The Effects of Non-Pharmaceutical Interventions on COVID-19 Epidemic Growth Rate during Pre- and Post-Vaccination Period in Asian Countries
    Huy, Le Duc
    Nguyen, Nhi Thi Hong
    Phuc, Phan Thanh
    Huang, Chung-Chien
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2022, 19 (03)