Enoxaparin improves COVID-19 by reducing Neutrophils Extracellular Traps (NETs) production

被引：4

作者：

Corneo, Emily S. ^{[1
,9
]}

Veras, Flavio Protasio ^{[1
,2
,3
,8
]}

Gomes, Giovanni F. ^{[2
,3
]}

Schneider, Ayda H. ^{[2
,3
]}

Manuella, Bruna ^{[2
,3
]}

Almeida, Cicero J. L. R. ^{[2
,3
]}

Silva, Camila M. ^{[2
,3
]}

Martins, Ronaldo B. ^{[4
]}

Batah, Sabrina S. ^{[7
]}

Simon, Carla S. ^{[1
]}

Prestes, Gabriele da S. ^{[1
]}

Alves-Filho, Jose Carlos ^{[2
,3
]}

Arruda, Eurico ^{[4
]}

Louzada-Junior, Paulo ^{[2
,5
,6
]}

de Oliveira, Rene D. R. ^{[5
,6
]}

Fabro, Alexandre T. ^{[7
]}

Cunha, Thiago M. ^{[2
,3
]}

Cunha, Fernando Queiroz ^{[1
,2
,3
]}

Dal-Pizzol, Felipe ^{[1
]}

机构：

[1] Univ Southern Santa Catarina UNESC, Lab Expt Pathophysiol, Grad Program Hlth Sci, Hlth Sci Unit, Criciuma, SC, Brazil

[2] Ribeirao Preto Med Sch, Ctr Res Inflammatory Dis CRID, Ribeirao Preto, Brazil

[3] Res Ctr, Dept Pharmacol, Sao Paulo, Brazil

[4] Res Ctr, Dept Virol, Sao Paulo, Brazil

[5] Univ Sao Paulo, Div Clin Immunol, Internal Med, Ribeirao Preto, SP, Brazil

[6] Univ Sao Paulo, Div Infect Dis, Ribeirao Preto, SP, Brazil

[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol & Legal Med, Ribeirao Preto, Brazil

[8] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ribeirao Preto, SP, Brazil

[9] Univ Southern Santa Catarina UNESC, Lab Expt Pathophysiol, Av Univ 1105, Criciuma, SC, Brazil

来源：

CLINICAL IMMUNOLOGY | 2023年 / 257卷

关键词：

SARS-CoV-2; Lung injury; Inflammatory markers; NETs; Enoxaparin; MORTALITY; HEPARIN;

D O I：

10.1016/j.clim.2023.109836

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: COVID-19 causes consequences such as imbalance of the immune system and thrombotic events. During the infection process, NETs in excess induce a pro-inflammatory response and disseminated intravascular coagulation. We evaluated the role of enoxaparin as a potential inhibitor of NETs.Methods: K18-hACE2 animals infected with the SARS-CoV-2 virus and a group of 23 individuals admitted to the hospital with COVID-19 treated with enoxaparin or without treatment and controls without the disease were included.Results: Enoxaparin decreased the levels of NETs, reduced the signs of the disease and mitigated lung damage in the animals infected with SARS-CoV-2. These effects were partially associated with prevention of SARS-CoV-2 entry and NETs synthesis. Clinical data revealed that treatment with enoxaparin decreased the levels of inflammatory markers, the levels of NETs in isolated neutrophils and the organ dysfunction.Conclusion: This study provides evidence for the beneficial effects of enoxaparin in COVID-19 in addition to its anticoagulant role.

引用

页数：12

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