Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane

被引：2
|
作者：
Rakhimova, Elena B. [1 ]
Kirsanov, Victor Yu. [1 ]
Kuzmina, Ulyana Sh. [2 ]
Galyautdinov, Ilgiz V. [2 ]
Vakhitova, Yulia V. [2 ]
机构：
[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa Fed Res Ctr, Ufa 450075, Russia
[2] Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa 450054, Russia
来源：
MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 01期
关键词：
catalysis; heterocyclization; trans-1; 2-diaminocyclohexane; anilines; polycyclic compounds; hexaazadibenzotetracenes; cytotoxic activity; ENANTIOSELECTIVE MICHAEL ADDITIONS; 1,3-DICARBONYL COMPOUNDS; ACIDS;
D O I：
10.1016/j.mencom.2023.01.035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot synthesis of N,N'-disubstituted (3bR*,7aR*,1 0bR*,14aR*)-octadecahydro-1H,8H- 2,3a,7b,9,10a,14b-hexaazadibenzo[fg, op]tetracenes via the catalytic heterocyclization of trans-1,6,7,12-tetraaza-perhydrotetracene with formaldehyde or CH2(NMe2)2 and anilines has been accomplished. Preliminary screening of thus obtained perhydro hexaazadibenzotetracenes for cytotoxic activity has been performed.
引用
收藏
页码：112 / 114
页数：3
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