Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer

被引：2
|
作者：
Qu, Ningxin [1 ,5 ]
Luan, Ting [2 ,6 ]
Liu, Naiquan [3 ,7 ]
Kong, Chenhui [1 ,5 ]
Xu, Le [1 ]
Yu, Hong [1 ,5 ]
Kang, Ye [4 ,8 ]
Han, Ye [1 ,5 ]
机构：
[1] China Med Univ, Shengjing Hosp, Breast Oncol Dept, Shenyang, Peoples R China
[2] China Med Univ, Shengjing Hosp, Dept Crit Care Med, Shenyang, Peoples R China
[3] China Med Univ, Shengjing Hosp, Nephrol Dept, Shenyang, Peoples R China
[4] China Med Univ, Shengjing Hosp, Pathol Dept, Shenyang, Peoples R China
[5] China Med Univ, Shengjing Hosp, Breast Oncol Dept, Shenyang 110004, Peoples R China
[6] China Med Univ, Shengjing Hosp, Dept Crit Care Med, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
[7] China Med Univ, Shengjing Hosp, Nephrol Dept, Shenyang 110004, Peoples R China
[8] China Med Univ, Shengjing Hosp, Pathol Dept, Shenyang 110004, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 169卷
基金：
中国国家自然科学基金;
关键词：
HNF4; alpha; Epigenetics; Tumor; DNA methylation; Histone; FACTOR; 4-ALPHA; HEPATOCELLULAR-CARCINOMA; MOLECULAR SUBTYPES; BARRETTS-ESOPHAGUS; VISCERAL ENDODERM; STEM-CELLS; EXPRESSION; HNF4A; LIVER; GENE;
D O I：
10.1016/j.biopha.2023.115923
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
HNF4 alpha, a transcription factor, plays a vital role in regulating functional genes and biological processes. Its alternative splicing leads to various transcript variants encoding different isoforms. The spotlight has shifted towards the extensive discussion on tumors interplayed withHNF4 alpha abnormalities. Aberrant HNF4 alpha expression has emerged as sentinel markers of epigenetic shifts, casting reverberations upon downstream target genes and intricate signaling pathways, most notably with cancer. This review provides a comprehensive overview of HNF4 alpha's involvement in tumor progression and metastasis, elucidating its role and underlying mechanisms.
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页数：10
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