One-pot synthesis of 2,6-diaryl-4,5-dihydropyridazin-3(2H)-ones: Copper catalyzed annulation of aldehydes, arylhydrazines and 3-acryloyloxazolidin-2-one

被引：0
|
作者：
Zhao, Jianbo
Lei, Shengshu
Wu, Min
Pang, Can
Li, Hao [1 ]
机构：
[1] East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Mei long Rd, Shanghai 200237, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 121卷
关键词：
Annulation; Copper; One; -pot; Pyridazinones; PROGESTERONE-RECEPTOR LIGANDS; BIOLOGICAL EVALUATION; PHTHALAZINONE DERIVATIVES; CARDIOTONIC AGENTS; PYRIDAZINONE; 4,5-DIHYDRO-3(2H)-PYRIDAZINONES; SELECTIVITY; AFFINITY; SERIES;
D O I：
10.1016/j.tetlet.2023.154473
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The three-component synthesis of pyridazinones from aldehydes, arylhydrazines and 3-acryloyloxazo-lidin-2-one catalyzed by Cu(OTf)2 has been developed. This strategy exhibits high tolerance towards many functional groups including various aliphatic, aromatic and hetero-aromatic aldehydes to give 2,6-diaryl-4,5-dihydropyridazin-3(2H)-one products in moderate to high yields.(c) 2023 Elsevier Ltd. All rights reserved.
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页数：4
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