Systemic inflammatory regulators and preeclampsia: a two-sample bidirectional Mendelian randomization study

被引:1
|
作者
Li, Chu [1 ]
Tian, Yishu [2 ]
Dougarem, Djouhayna [3 ]
Sun, Litao [2 ]
Zhong, Zixing [1 ]
机构
[1] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Ctr Reprod Med, Hangzhou, Peoples R China
[2] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Ctr Reprod Med,Dept Ultrasound Med, Hangzhou, Peoples R China
[3] Zhejiang Univ, Sch Med, Hosp Obstet & Gynecol, Hangzhou, Peoples R China
关键词
cytokines; inflammation; preeclampsia; pregnancy; Mendelian randomization study; MIGRATION INHIBITORY FACTOR; INDUCED HYPERTENSION; MIF; PATHOPHYSIOLOGY; PREGNANCY; VARIANTS; DISEASE; SERUM; RISK;
D O I
10.3389/fgene.2024.1359579
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Systemic inflammatory regulators have been associated with preeclampsia (PE) during pregnancy; however, there is inconsistent evidence from animal models and observational results.Methods: Using summary data from genome-wide association studies (GWASs), we performed a bidirectional Mendelian randomization (MR) analysis of two samples of systemic inflammatory regulators (n = 8,186) and PE (n = 267,242) individuals of European ancestry. As our primary analysis, we used the random-effects inverse-variance weighted (IVW) approach. Sensitivity and pleiotropy analyses were conducted using the MR-Egger method, weighted median, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and Cochran's Q test.Results: The results indicate that there is a correlation between a higher circulating level of tumor necrosis factor alpha (TNF-alpha) and interleukin-9 (IL-9) and an increased risk of PE (odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.09-1.60, p = 0.004 and OR = 1.28, 95% CI: 1.02-1.62, p = 0.033, respectively). Conversely, lower levels of stem cell growth factor beta (SCGF-beta) (OR = 0.89, 95% CI: 0.80-0.99, p = 0.027) and interleukin-5 (IL-5) (OR = 0.80, 95% CI: 0.65-0.98, p = 0.030) are linked to an increased risk of PE. The macrophage migration inhibitory factor (MIF) is the downstream inflammatory regulator of PE, according to reverse magnetic resonance imaging studies.Conclusion: Our study suggests that SCGF-beta, IL-5, IL-9, and TNF-alpha causally affect the PE risk, while PE is causally associated with MIF. Further studies are needed to validate these biomarkers in managing PE.
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页数:8
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