Pathogenesis of Depression in Alzheimer's Disease

被引：4
|
作者：
Zhan, Qingyang [1 ]
Kong, Fanyi [1 ]
Shao, Shuai [1 ]
Zhang, Bo [1 ]
Huang, Shuming [1 ]
机构：
[1] Heilongjiang Univ Chinese Med, Inst Chinese Med, Harbin 150040, Peoples R China
来源：
NEUROCHEMICAL RESEARCH | 2024年 / 49卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's Disease; Depression; Serotonin; Neuro-inflammation; HPA axis; BDNF; Glutamate; Hippocampal atrophy; AMYLOID-BETA OLIGOMERS; LONG-TERM DEPRESSION; D-ASPARTATE RECEPTOR; NEUROTROPHIC FACTOR; OLDER-ADULTS; MOUSE MODEL; HIPPOCAMPAL; DOPAMINE; NEUROGENESIS; DYSFUNCTION;
D O I：
10.1007/s11064-023-04061-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Depression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (BDNF), and hippocampal atrophy. This review consolidates research findings from pertinent fields to elucidate the mechanisms underlying depression in Alzheimer's disease, aiming to provide valuable insights for the study of its mechanisms and clinical treatment.
引用
收藏
页码：548 / 556
页数：9
相关论文
共 50 条
  • [41] The role of amyloid β in the pathogenesis of Alzheimer's disease
    Gilbert, Barnabas James
    POSTGRADUATE MEDICAL JOURNAL, 2014, 90 (1060) : 113 - 117
  • [42] Choline Transporters and The Pathogenesis of Alzheimer's Disease
    Deng Li
    Wang Jin-Zhao
    Yang Li
    Long Cheng
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 41 (12) : 1207 - 1213
  • [43] Porphyromonas gingivalis and the pathogenesis of Alzheimer's disease
    Liu, Sixin
    Butler, Catherine A.
    Ayton, Scott
    Reynolds, Eric C.
    Dashper, Stuart G.
    CRITICAL REVIEWS IN MICROBIOLOGY, 2024, 50 (02) : 127 - 137
  • [44] Presenilin mutation and Alzheimer's disease pathogenesis
    Tabira, T
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S564 - S564
  • [45] The Convergence of Alzheimer's Disease Pathogenesis Concepts
    Kozin, S. A.
    Makarov, A. A.
    MOLECULAR BIOLOGY, 2019, 53 (06) : 896 - 903
  • [46] Lipids and the pathogenesis of Alzheimer's disease: Is there a link?
    Mielke, M. M.
    Lyketsos, C. G.
    INTERNATIONAL REVIEW OF PSYCHIATRY, 2006, 18 (02) : 173 - 186
  • [47] Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis
    Cascella, Roberta
    Cecchi, Cristina
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (09)
  • [48] Adult neurogenesis and the pathogenesis of Alzheimer's disease
    Taupin, Philippe
    MEDICAL SCIENCE MONITOR, 2009, 15 (03): : LE1 - LE1
  • [49] Alzheimer's Disease Pathogenesis Role of Aging
    Harman, Denham
    UNDERSTANDING AND MODULATING AGING, 2006, 1067 : 454 - 460
  • [50] The role of acetylicholinesterase in the pathogenesis of Alzheimer's disease
    Rees, TM
    Brimijoin, S
    DRUGS OF TODAY, 2003, 39 (01) : 75 - 83
12345